TY - JOUR
T1 - MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in Mice
AU - Bonauer, Angelika
AU - Carmona, Guillaume
AU - Iwasaki, Masayoshi
AU - Mione, Marina
AU - Koyanagi, Masamichi
AU - Fischer, Ariane
AU - Burchfield, Jana
AU - Fox, Henrik
AU - Doebele, Carmen
AU - Ohtani, Kisho
AU - Chavakis, Emmanouil
AU - Potente, Michael
AU - Tjwa, Marc
AU - Urbich, Carmen
AU - Zeiher, Andreas M.
AU - Dimmeler, Stefanie
PY - 2009/6/26
Y1 - 2009/6/26
N2 - MicroRNAs (miRs) are small noricoding RNAs that regulate gene expression by binding to target messenger RNAs (mRNAs), leading to translational repression or degradation. Here, we show that the miR-17-92 cluster is highly expressed in human endothelial cells and that miR-92a, a component of this cluster, controls the growth of new blood vessels (angiogenesis). Forced overexpression of miR-92a in endothelial cells blocked angiogenesis in vitro and in vivo. In mouse models of limb ischemia and myocardial infarction, systemic administration of an antagomir designed to inhibit miR-92a led to enhanced blood vessel growth and functional recovery of damaged tissue. MiR-92a appears to target mRNAs corresponding to several proangiogenic proteins, including the integrin subunit alpha5. Thus, miR-92a may serve as a valuable therapeutic target in the setting of ischemic disease.
AB - MicroRNAs (miRs) are small noricoding RNAs that regulate gene expression by binding to target messenger RNAs (mRNAs), leading to translational repression or degradation. Here, we show that the miR-17-92 cluster is highly expressed in human endothelial cells and that miR-92a, a component of this cluster, controls the growth of new blood vessels (angiogenesis). Forced overexpression of miR-92a in endothelial cells blocked angiogenesis in vitro and in vivo. In mouse models of limb ischemia and myocardial infarction, systemic administration of an antagomir designed to inhibit miR-92a led to enhanced blood vessel growth and functional recovery of damaged tissue. MiR-92a appears to target mRNAs corresponding to several proangiogenic proteins, including the integrin subunit alpha5. Thus, miR-92a may serve as a valuable therapeutic target in the setting of ischemic disease.
UR - http://www.scopus.com/inward/record.url?scp=67649998366&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67649998366&partnerID=8YFLogxK
U2 - 10.1126/science.1174381
DO - 10.1126/science.1174381
M3 - Article
C2 - 19460962
AN - SCOPUS:67649998366
SN - 0036-8075
VL - 324
SP - 1710
EP - 1713
JO - Science
JF - Science
IS - 5935
ER -
