microRNA-based cancer cell reprogramming technology (review)

Shimpei Nishikawa, Hideshi Ishii, Naotsugu Haraguchi, Yoshihiro Kano, Takahito Fukusumi, Katsuya Ohta, Miyuki Ozaki, Dyah Laksmi Dewi, Daisuke Sakai, Taroh Satoh, Hiroaki Nagano, Yuichiro Doki, Masaki Mori

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Epigenetic modifications play crucial roles in cancer initiation and development. Complete reprogramming can be achieved through the introduction of defined biological factors such as Oct4, Sox2, Klf4, and cMyc into mouse and human fibroblasts. Introduction of these transcription factors resulted in the modification of malignant phenotype behavior. Recent studies have shown that human and mouse somatic cells can be reprogrammed to become induced pluripotent stem cells using forced expression of microRNAs, which completely eliminates the need for ectopic protein expression. Considering the usefulness of RNA molecules, microRNA-based reprogramming technology may have future applications in regenerative and cancer medicine.

Original languageEnglish
Pages (from-to)8-14
Number of pages7
JournalExperimental and Therapeutic Medicine
Volume4
Issue number1
DOIs
Publication statusPublished - Jul 2012

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology (miscellaneous)
  • Cancer Research

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