MicroRNAs as biomarkers in colorectal cancer

Takaaki Masuda, Naoki Hayashi, Yosuke Kuroda, Shuhei Ito, Hidetoshi Eguchi, Koshi Mimori

Research output: Contribution to journalReview article

59 Citations (Scopus)

Abstract

MicroRNAs (miRs) are small RNAs that repress mRNA translation, resulting in the degradation of mRNAs and regulation of the expression levels of various genes. Recent studies have shown that aberrant miR expression has a functional role in the initiation and progression of various malignancies, including colorectal cancer (CRC), which is one of the leading causes of cancer-related death worldwide. miRs have also been shown to have applications as diagnostic, prognostic, and predictive biomarkers because of their high tissue specificity, stability, and altered expression in tumor development. In this report, we examined the role of miRs as biomarkers in CRC through a review of meta-analyses and large-scale analyses having strong statistical confidence in the study outcomes. We also discuss current issues in the clinical application of these miRs.

Original languageEnglish
Article number124
JournalCancers
Volume9
Issue number9
DOIs
Publication statusPublished - Sep 13 2017

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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