MicroRNAs in human malignant gliomas

Masahiro Mizoguchi, Yanlei Guan, Koji Yoshimoto, Nobuhiro Hata, Toshiyuki Amano, Akira Nakamizo, Tomio Sasaki

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

MicroRNA (miRNA) is a new class of small noncoding RNA molecules that regulate a wide spectrum of gene expression in a posttranscriptional manner. MiRNAs play crucial roles in tumorigenesis, angiogenesis, invasion, and apoptosis for various types of tumor. Recent studies have identified dysregulation of specific miRNAs in malignant gliomas. Global expression profiling of miRNAs has revealed several miRNAs clinically implicated in human glioblastomas. Some miRNAs are clearly associated with clinical outcome and chemo- and radio-therapy resistance in these tumors. Furthermore, miRNAs also regulate specific signaling pathways, including the critical core pathways in glioblastoma. As a result, miRNAs have the potential to affect the responses to molecular-targeted therapies. More recent studies have revealed that miRNAs might be associated with cancer stem cell properties, affecting tumor maintenance and progression. Recent investigation have revealed that miRNAs are not only biological markers with diagnostic implications, but also one of the most promising treatment targets in human glioblastoma. Herein, we summarized the novel insights of miRNAs into human malignant gliomas.

Original languageEnglish
Article number732874
JournalJournal of Oncology
DOIs
Publication statusPublished - Aug 17 2012

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MicroRNAs
Glioma
Glioblastoma
Molecular Targeted Therapy
Small Untranslated RNA
Neoplasms
Critical Pathways
Neoplastic Stem Cells
Radio
Carcinogenesis
Therapeutics
Biomarkers
Maintenance
Apoptosis
Gene Expression

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Mizoguchi, M., Guan, Y., Yoshimoto, K., Hata, N., Amano, T., Nakamizo, A., & Sasaki, T. (2012). MicroRNAs in human malignant gliomas. Journal of Oncology, [732874]. https://doi.org/10.1155/2012/732874

MicroRNAs in human malignant gliomas. / Mizoguchi, Masahiro; Guan, Yanlei; Yoshimoto, Koji; Hata, Nobuhiro; Amano, Toshiyuki; Nakamizo, Akira; Sasaki, Tomio.

In: Journal of Oncology, 17.08.2012.

Research output: Contribution to journalReview article

Mizoguchi M, Guan Y, Yoshimoto K, Hata N, Amano T, Nakamizo A et al. MicroRNAs in human malignant gliomas. Journal of Oncology. 2012 Aug 17. 732874. https://doi.org/10.1155/2012/732874
Mizoguchi, Masahiro ; Guan, Yanlei ; Yoshimoto, Koji ; Hata, Nobuhiro ; Amano, Toshiyuki ; Nakamizo, Akira ; Sasaki, Tomio. / MicroRNAs in human malignant gliomas. In: Journal of Oncology. 2012.
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