Microsatellite instability and somatic mutations in endometrial carcinomas

Takako Sakamoto, Takayuki Murase, Hironobu Urushibata, Kiyoko Kato, Hiroyuki Takada, Toshiro Imamura, Hiroyuki Mori, Norio Wake

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Abstract

Recently, microsatellite instability (MI) has been demonstrated in some types of human cancers. In this study, we attempted to determine the frequency of MI in endometrial cancers and evaluate whether replication error (RER)-positive phenotype is correlated with known genetic mutations or the aberrations of other pathways in endometrial cancers. Seventy-two primary endometrial cancers were examined for microsatellite instability. Eleven tumors (15%) had RERs at two or more microsatellite loci, suggesting that generalized MI may be a molecular manifestation of endometrial cancers. We next examined whether the MI was associated with changes in the K-ras protooncogene, p53 tumor suppressor gene, and 18q LOH, which were frequently detected in endometrial cancers. The MI did not confer the potential to produce point mutations in the K-ras gene or 18q LOH, whereas the data were insufficient to identify the correlation between MI and p53 mutations in the cancers. These results suggest the presence of multiple mutation subsets that act in a complementary fashion in endometrial cancer development.

Original languageEnglish
Pages (from-to)53-58
Number of pages6
JournalGynecologic Oncology
Volume71
Issue number1
DOIs
Publication statusPublished - Jan 1 1998

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Sakamoto, T., Murase, T., Urushibata, H., Kato, K., Takada, H., Imamura, T., ... Wake, N. (1998). Microsatellite instability and somatic mutations in endometrial carcinomas. Gynecologic Oncology, 71(1), 53-58. https://doi.org/10.1006/gyno.1998.5154