Microsatellite instability in gastrointestinal tract cancers: A brief update

Shinya Oda, Yan Zhao, Yoshihiko Maehara

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Microsatellite instability (MSI) was initially reported in colorectal cancer and, particularly, in hereditary nonpolyposis colorectal cancer (HNPCC). Since mutations in the genes functioning in DNA mismatch repair (MMR) were found in HNPCC kindred, this phenotype has been connected to a deficiency in MMR. The MSI+ phenotype is associated with various human malignancies. As MSI+ tumors appear to form a unique clinicopathological and molecular entity that is clearly distinct from that of classical colorectal tumors, which are accompanied by chromosomal instability (CIN), an exclusive pathway of tumorigenesis has been proposed in colorectal cancer. However, this scheme, comprising two mutually exclusive pathways, is now being reexamined, in light of a series of evidence accumulating in the literature, which relates to (a) distinction between high-level MSI (MSI-H) and low-level MSI (MSI-L), (b) heterogeneity in MSI-H, particularly in the sporadic and hereditary settings, (c) molecular mechanisms underlying the MSI+ phenotypes, and (d) relationships between the MSI+ and CIN phenotypes. Several molecular mechanisms may underlie repeat instability in eukaryotic cells. The relationship between MSI and defective MMR may be more complicated than has been suspected. The role of MMR deficiency in tumorigenesis in the digestive tract appears to be diverse and is not simple, even in the colorectum.

Original languageEnglish
Pages (from-to)1005-1015
Number of pages11
JournalSurgery today
Volume35
Issue number12
DOIs
Publication statusPublished - Dec 2005

All Science Journal Classification (ASJC) codes

  • Surgery

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