Microstructure evolution in Stöber-type silica nanoparticles and their in vitro apatite deposition

Song Chen, Akiyoshi Osaka, Satoshi Hayakawa, Kanji Tsuru, Eiji Fujii, Koji Kawabata

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Prepared via Stöber-type sol-gel routes were three types of silica particles of <1 μm in size: pure silica, Ca-involving silica, and chitosan/alginate-coated silica with a polymershell-silica core structure. Calcium ions were impregnated in the organic layers of the polymer-coated silica particle. The sol-gel procedure was applied to tetraethoxysilane dissolved in an ethanol/water mixture, while Ca-silica was derived from CaCl 2-containing ethanol/water solutions. Scanning and transmission electron micrograph analyses indicated that those silica particles consisted of ~10 nm primary particles, the Ca-silica particles (~500 nm) were larger than the Ca-free ones (~200 nm) and that their size increased with the Ca concentration in the precursor solutions. From 1H- and 29Si- magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectra and 29Si cross-polarization NMR spectra, the mechanism of primary particle agglomeration and degradation of the secondary particles in saline were discussed in terms of the content of H2O molecules and >Si-OH as well as hydrogen bonding interactions among them. In addition, the Ca-silica and core-shell silica deposited apatite in Kokubo's simulated body fluid. Thus, the present Ca-silica and polymer-coated silica particles were suggested to be applicable to injectable bone fillers for bone generation.

Original languageEnglish
Pages (from-to)322-335
Number of pages14
JournalJournal of Sol-Gel Science and Technology
Volume48
Issue number3
DOIs
Publication statusPublished - Dec 1 2008

Fingerprint

Apatites
Apatite
apatites
Silicon Dioxide
Silica
Nanoparticles
silicon dioxide
nanoparticles
microstructure
Microstructure
bones
Bone
body fluids
Body fluids
fillers
Particles (particulate matter)
Sol-gels
Fillers
Hydrogen bonds
Polymers

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Biomaterials
  • Condensed Matter Physics
  • Materials Chemistry

Cite this

Microstructure evolution in Stöber-type silica nanoparticles and their in vitro apatite deposition. / Chen, Song; Osaka, Akiyoshi; Hayakawa, Satoshi; Tsuru, Kanji; Fujii, Eiji; Kawabata, Koji.

In: Journal of Sol-Gel Science and Technology, Vol. 48, No. 3, 01.12.2008, p. 322-335.

Research output: Contribution to journalArticle

Chen, Song ; Osaka, Akiyoshi ; Hayakawa, Satoshi ; Tsuru, Kanji ; Fujii, Eiji ; Kawabata, Koji. / Microstructure evolution in Stöber-type silica nanoparticles and their in vitro apatite deposition. In: Journal of Sol-Gel Science and Technology. 2008 ; Vol. 48, No. 3. pp. 322-335.
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