Midline crossing and Slit responsiveness of commissural axons require USP33

Junichi Yuasa-Kawada, Mariko Kinoshita-Kawada, Guan Wu, Yi Rao, Jane Y. Wu

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Commissural axons cross the ventral midline of the neural tube in a Slit-dependent manner. The underlying molecular mechanisms remain unclear. We found that the deubiquitinating enzyme USP33 interacts with the Robo1 receptor. USP33 was essential for midline crossing by commissural axons and for their response to Slit. Our results reveal a previously unknown role for USP33 in vertebrate commissural axon guidance and in Slit signaling.

Original languageEnglish
Pages (from-to)1087-1089
Number of pages3
JournalNature Neuroscience
Volume12
Issue number9
DOIs
Publication statusPublished - Sep 1 2009

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Axons
Neural Tube
Vertebrates
Axon Guidance
Deubiquitinating Enzymes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Yuasa-Kawada, J., Kinoshita-Kawada, M., Wu, G., Rao, Y., & Wu, J. Y. (2009). Midline crossing and Slit responsiveness of commissural axons require USP33. Nature Neuroscience, 12(9), 1087-1089. https://doi.org/10.1038/nn.2382

Midline crossing and Slit responsiveness of commissural axons require USP33. / Yuasa-Kawada, Junichi; Kinoshita-Kawada, Mariko; Wu, Guan; Rao, Yi; Wu, Jane Y.

In: Nature Neuroscience, Vol. 12, No. 9, 01.09.2009, p. 1087-1089.

Research output: Contribution to journalArticle

Yuasa-Kawada, J, Kinoshita-Kawada, M, Wu, G, Rao, Y & Wu, JY 2009, 'Midline crossing and Slit responsiveness of commissural axons require USP33', Nature Neuroscience, vol. 12, no. 9, pp. 1087-1089. https://doi.org/10.1038/nn.2382
Yuasa-Kawada J, Kinoshita-Kawada M, Wu G, Rao Y, Wu JY. Midline crossing and Slit responsiveness of commissural axons require USP33. Nature Neuroscience. 2009 Sep 1;12(9):1087-1089. https://doi.org/10.1038/nn.2382
Yuasa-Kawada, Junichi ; Kinoshita-Kawada, Mariko ; Wu, Guan ; Rao, Yi ; Wu, Jane Y. / Midline crossing and Slit responsiveness of commissural axons require USP33. In: Nature Neuroscience. 2009 ; Vol. 12, No. 9. pp. 1087-1089.
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