Migraine with aura and recurrent vertigo attacks in a patient with hereditary hemorrhagic telangiectasia

Tomomi Yonekawa, Hikaru Doi, Takahisa Tateishi, Koji Tanaka, Tomo Iura, Yasumasa Ohyagi, Jun Ichi Kira

Research output: Contribution to journalArticlepeer-review


Hereditary hemorrhagic telangiectasia (HHT) is characterized by systemic vascular diseases mainly shown as arterio-visnous fistula (AVF). Here, we presented a 29-year-old woman with HHT complicated with migraine with aura (MWA) and vertigo. At the age of twelve years, she developed migraine with visual aura. At that time, migraine attacks were seen three times a year. At the age of 29 years, she also developed speech disturbance as migraine aura. At the ages of 20 and 29 years, she repeatedly suffered from positional vertigo attacks for a month. Physical examination revealed dilation of the capillary vessels at tongue, soft palate, and nasal mucosa and AVFs were located in the upper cervical cord, parietal lobe, and bilateral lungs. These clinical findings were consistent with the diagnostic criteria of HHT. Embolization of pulmonary AVF decreased the frequency of migraine attacks during 2-year follow-up after the embolization. The frequency of migraine in patients with HHT is higher than that of general population as well as the prevalence of vertigo. Therefore, MWA and vertigo presented in the patient with HHT suggests that there is a common pathological mechanism of dysfunction of endothelial cells and R-L shunt, among HHT, MWA, and vertigo.

Original languageEnglish
Pages (from-to)499-502
Number of pages4
JournalClinical Neurology
Issue number7
Publication statusPublished - Jul 2012

All Science Journal Classification (ASJC) codes

  • Clinical Neurology


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