Milk and dairy consumption and risk of dementia in an elderly Japanese population: The hisayama study

Mio Ozawa, Tomoyuki Ohara, Toshiharu Ninomiya, Jun Hata, Daigo Yoshida, Naoko Mukai, Masaharu Nagata, Kazuhiro Uchida, Tomoko Shirota, Takanari Kitazono, Yutaka Kiyohara

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Abstract

Objectives To determine the effect of milk and dairy intake on the development of all-cause dementia and its subtypes in an elderly Japanese population. Design Prospective cohort study. Setting The Hisayama Study, Japan. Participants Individuals aged 60 and older without dementia (N = 1,081). Measurements Milk and dairy intake was estimated using a 70-item semiquantitative food frequency questionnaire grouped into quartiles. The risk estimates of milk and dairy intake on the development of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were computed using a Cox proportional hazards model. Results Over 17 years of follow-up, 303 subjects developed all-cause dementia; 166 had AD, and 98 had VaD. The age- and sex-adjusted incidence of all-cause dementia, AD, and VaD significantly decreased as milk and dairy intake level increased (P for trend =.03 for all-cause dementia,.04 for AD,.01 for VaD). After adjusting for potential confounders, the linear relationship between milk and dairy intake and development of AD remained significant (P for trend =.03), whereas the relationships with all-cause dementia and VaD were not significant. The risk of AD was significantly lower in the second, third, and fourth quartiles of milk and dairy intake than in the first quartile. Conclusion Greater milk and dairy intake reduced the risk of dementia, especially AD, in the general Japanese population.

Original languageEnglish
Pages (from-to)1224-1230
Number of pages7
JournalJournal of the American Geriatrics Society
Volume62
Issue number7
DOIs
Publication statusPublished - Jul 2014

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Dementia
Alzheimer Disease
Milk
Vascular Dementia
Population
Proportional Hazards Models
Japan
Cohort Studies
Prospective Studies
Food
Incidence

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology

Cite this

Milk and dairy consumption and risk of dementia in an elderly Japanese population : The hisayama study. / Ozawa, Mio; Ohara, Tomoyuki; Ninomiya, Toshiharu; Hata, Jun; Yoshida, Daigo; Mukai, Naoko; Nagata, Masaharu; Uchida, Kazuhiro; Shirota, Tomoko; Kitazono, Takanari; Kiyohara, Yutaka.

In: Journal of the American Geriatrics Society, Vol. 62, No. 7, 07.2014, p. 1224-1230.

Research output: Contribution to journalArticle

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AU - Hata, Jun

AU - Yoshida, Daigo

AU - Mukai, Naoko

AU - Nagata, Masaharu

AU - Uchida, Kazuhiro

AU - Shirota, Tomoko

AU - Kitazono, Takanari

AU - Kiyohara, Yutaka

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