Minimal clinically important differences in Toronto Extremity Salvage Score for patients with lower extremity sarcoma

Koichi Ogura, Kosuke Uehara, Toru Akiyama, Yusuke Shinoda, Shintaro Iwata, Satoshi Tsukushi, Eisuke Kobayashi, Takeshi Hirose, Tsukasa Yonemoto, Makoto Endo, Yoshikazu Tanzawa, Fumihiko Nakatani, Hirotaka Kawano, Sakae Tanaka, Akira Kawai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The Toronto Extremity Salvage Score (TESS) is the most widely used patient-reported outcome measure for orthopaedic oncology patients. However, minimal clinically important differences (MCIDs) in the TESS have not been analyzed. The aim of this study was to define the MCIDs of TESS in patients with lower extremity sarcoma. Methods: A total of 85 patients were investigated to calculate the MCIDs for TESS. Three different methods were used: 1) distribution-based methods based on one-half of the standard deviation and standard error of measurement (SEM) at the baseline, 2) anchor-based and receiver operating characteristic (ROC) analysis, and 3) anchor-based using Akaike's Information Criterion (AIC) analysis. Results: The MCIDs at 6 months were 4.9–7.8 by distribution-based methods and 4.3–4.4 by anchor-based methods. The MCIDs at 12 months were 4.0–6.9 by distribution-based methods and 10.6–11.6 by anchor-based methods. Conclusions: We calculated MCID values for the TESS based on distribution- and anchor-based approaches. Our results seem reasonable since MCIDs calculated by the different approaches had similar values. This knowledge will enable clinicians to identify meaningful functional improvements in sarcoma patients.

Original languageEnglish
JournalJournal of Orthopaedic Science
DOIs
Publication statusPublished - Jan 1 2019
Externally publishedYes

Fingerprint

Sarcoma
Lower Extremity
Extremities
Minimal Clinically Important Difference
ROC Curve
Orthopedics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Minimal clinically important differences in Toronto Extremity Salvage Score for patients with lower extremity sarcoma. / Ogura, Koichi; Uehara, Kosuke; Akiyama, Toru; Shinoda, Yusuke; Iwata, Shintaro; Tsukushi, Satoshi; Kobayashi, Eisuke; Hirose, Takeshi; Yonemoto, Tsukasa; Endo, Makoto; Tanzawa, Yoshikazu; Nakatani, Fumihiko; Kawano, Hirotaka; Tanaka, Sakae; Kawai, Akira.

In: Journal of Orthopaedic Science, 01.01.2019.

Research output: Contribution to journalArticle

Ogura, K, Uehara, K, Akiyama, T, Shinoda, Y, Iwata, S, Tsukushi, S, Kobayashi, E, Hirose, T, Yonemoto, T, Endo, M, Tanzawa, Y, Nakatani, F, Kawano, H, Tanaka, S & Kawai, A 2019, 'Minimal clinically important differences in Toronto Extremity Salvage Score for patients with lower extremity sarcoma', Journal of Orthopaedic Science. https://doi.org/10.1016/j.jos.2019.03.022
Ogura, Koichi ; Uehara, Kosuke ; Akiyama, Toru ; Shinoda, Yusuke ; Iwata, Shintaro ; Tsukushi, Satoshi ; Kobayashi, Eisuke ; Hirose, Takeshi ; Yonemoto, Tsukasa ; Endo, Makoto ; Tanzawa, Yoshikazu ; Nakatani, Fumihiko ; Kawano, Hirotaka ; Tanaka, Sakae ; Kawai, Akira. / Minimal clinically important differences in Toronto Extremity Salvage Score for patients with lower extremity sarcoma. In: Journal of Orthopaedic Science. 2019.
@article{8f0611eec99a45a590dec9e226b0851e,
title = "Minimal clinically important differences in Toronto Extremity Salvage Score for patients with lower extremity sarcoma",
abstract = "Background: The Toronto Extremity Salvage Score (TESS) is the most widely used patient-reported outcome measure for orthopaedic oncology patients. However, minimal clinically important differences (MCIDs) in the TESS have not been analyzed. The aim of this study was to define the MCIDs of TESS in patients with lower extremity sarcoma. Methods: A total of 85 patients were investigated to calculate the MCIDs for TESS. Three different methods were used: 1) distribution-based methods based on one-half of the standard deviation and standard error of measurement (SEM) at the baseline, 2) anchor-based and receiver operating characteristic (ROC) analysis, and 3) anchor-based using Akaike's Information Criterion (AIC) analysis. Results: The MCIDs at 6 months were 4.9–7.8 by distribution-based methods and 4.3–4.4 by anchor-based methods. The MCIDs at 12 months were 4.0–6.9 by distribution-based methods and 10.6–11.6 by anchor-based methods. Conclusions: We calculated MCID values for the TESS based on distribution- and anchor-based approaches. Our results seem reasonable since MCIDs calculated by the different approaches had similar values. This knowledge will enable clinicians to identify meaningful functional improvements in sarcoma patients.",
author = "Koichi Ogura and Kosuke Uehara and Toru Akiyama and Yusuke Shinoda and Shintaro Iwata and Satoshi Tsukushi and Eisuke Kobayashi and Takeshi Hirose and Tsukasa Yonemoto and Makoto Endo and Yoshikazu Tanzawa and Fumihiko Nakatani and Hirotaka Kawano and Sakae Tanaka and Akira Kawai",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.jos.2019.03.022",
language = "English",
journal = "Journal of Orthopaedic Science",
issn = "0949-2658",
publisher = "Springer Japan",

}

TY - JOUR

T1 - Minimal clinically important differences in Toronto Extremity Salvage Score for patients with lower extremity sarcoma

AU - Ogura, Koichi

AU - Uehara, Kosuke

AU - Akiyama, Toru

AU - Shinoda, Yusuke

AU - Iwata, Shintaro

AU - Tsukushi, Satoshi

AU - Kobayashi, Eisuke

AU - Hirose, Takeshi

AU - Yonemoto, Tsukasa

AU - Endo, Makoto

AU - Tanzawa, Yoshikazu

AU - Nakatani, Fumihiko

AU - Kawano, Hirotaka

AU - Tanaka, Sakae

AU - Kawai, Akira

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: The Toronto Extremity Salvage Score (TESS) is the most widely used patient-reported outcome measure for orthopaedic oncology patients. However, minimal clinically important differences (MCIDs) in the TESS have not been analyzed. The aim of this study was to define the MCIDs of TESS in patients with lower extremity sarcoma. Methods: A total of 85 patients were investigated to calculate the MCIDs for TESS. Three different methods were used: 1) distribution-based methods based on one-half of the standard deviation and standard error of measurement (SEM) at the baseline, 2) anchor-based and receiver operating characteristic (ROC) analysis, and 3) anchor-based using Akaike's Information Criterion (AIC) analysis. Results: The MCIDs at 6 months were 4.9–7.8 by distribution-based methods and 4.3–4.4 by anchor-based methods. The MCIDs at 12 months were 4.0–6.9 by distribution-based methods and 10.6–11.6 by anchor-based methods. Conclusions: We calculated MCID values for the TESS based on distribution- and anchor-based approaches. Our results seem reasonable since MCIDs calculated by the different approaches had similar values. This knowledge will enable clinicians to identify meaningful functional improvements in sarcoma patients.

AB - Background: The Toronto Extremity Salvage Score (TESS) is the most widely used patient-reported outcome measure for orthopaedic oncology patients. However, minimal clinically important differences (MCIDs) in the TESS have not been analyzed. The aim of this study was to define the MCIDs of TESS in patients with lower extremity sarcoma. Methods: A total of 85 patients were investigated to calculate the MCIDs for TESS. Three different methods were used: 1) distribution-based methods based on one-half of the standard deviation and standard error of measurement (SEM) at the baseline, 2) anchor-based and receiver operating characteristic (ROC) analysis, and 3) anchor-based using Akaike's Information Criterion (AIC) analysis. Results: The MCIDs at 6 months were 4.9–7.8 by distribution-based methods and 4.3–4.4 by anchor-based methods. The MCIDs at 12 months were 4.0–6.9 by distribution-based methods and 10.6–11.6 by anchor-based methods. Conclusions: We calculated MCID values for the TESS based on distribution- and anchor-based approaches. Our results seem reasonable since MCIDs calculated by the different approaches had similar values. This knowledge will enable clinicians to identify meaningful functional improvements in sarcoma patients.

UR - http://www.scopus.com/inward/record.url?scp=85064264266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064264266&partnerID=8YFLogxK

U2 - 10.1016/j.jos.2019.03.022

DO - 10.1016/j.jos.2019.03.022

M3 - Article

AN - SCOPUS:85064264266

JO - Journal of Orthopaedic Science

JF - Journal of Orthopaedic Science

SN - 0949-2658

ER -