Minimally-invasive local injection by electrically-driven narrow orifice channel

Kazuki Takahashi, Shun Omi, Yoko Yamanishi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We have successfully developed minimally-invasive needle-free bubble injector designed for the usage in air. The novelty is that the minimally-invasiveness of injection whose resolution is less than 10 μm, and hence cellular-scale injection can be possible without any pain. The novelty of the present techniques are (1) unique robust thick structure at the tip of the narrowed glass capillary for operation in air, (2) damper structure produce closed space to fill in reagent which enabled the injector to be used in air and (3) construction part to support inner probe to make self-aligned coaxial positioning for accurate injection. The injector can be used for any kind of materials with various hardness, owing to the strong impact of cavitation phenomenon when the high-speed micro-bubbles are collapsed. The fine adjustment of injection can be controlled by the number of applied electric pulses. The developed injector can be used for wide range of biomedical study, especially in gene therapy. This technique has advantages over the conventional electroporation or ultrasound operation in terms of localization of injection and ability of transportation of material.

Original languageEnglish
Title of host publication2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479966790
DOIs
Publication statusPublished - Jan 9 2015
Event2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014 - Nagoya, Japan
Duration: Nov 10 2014Nov 12 2014

Publication series

Name2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014

Other

Other2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014
CountryJapan
CityNagoya
Period11/10/1411/12/14

Fingerprint

Orifices
Air
Gene therapy
Bubbles (in fluids)
Cavitation
Needles
Ultrasonics
Hardness
Glass

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering
  • Mechanical Engineering

Cite this

Takahashi, K., Omi, S., & Yamanishi, Y. (2015). Minimally-invasive local injection by electrically-driven narrow orifice channel. In 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014 [7006059] (2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MHS.2014.7006059

Minimally-invasive local injection by electrically-driven narrow orifice channel. / Takahashi, Kazuki; Omi, Shun; Yamanishi, Yoko.

2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014. Institute of Electrical and Electronics Engineers Inc., 2015. 7006059 (2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Takahashi, K, Omi, S & Yamanishi, Y 2015, Minimally-invasive local injection by electrically-driven narrow orifice channel. in 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014., 7006059, 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014, Institute of Electrical and Electronics Engineers Inc., 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014, Nagoya, Japan, 11/10/14. https://doi.org/10.1109/MHS.2014.7006059
Takahashi K, Omi S, Yamanishi Y. Minimally-invasive local injection by electrically-driven narrow orifice channel. In 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014. Institute of Electrical and Electronics Engineers Inc. 2015. 7006059. (2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014). https://doi.org/10.1109/MHS.2014.7006059
Takahashi, Kazuki ; Omi, Shun ; Yamanishi, Yoko. / Minimally-invasive local injection by electrically-driven narrow orifice channel. 2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014. Institute of Electrical and Electronics Engineers Inc., 2015. (2014 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2014).
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