Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model

Lu Ni; Takeshi Yamada; Asako Murata; Kazuhiko Nakatani

doi:10.1039/d1cc06936e

Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model

Lu Ni, Takeshi Yamada, Asako Murata, Kazuhiko Nakatani

Research output: Contribution to journal › Article › peer-review

Abstract

Circular RNA (circRNA) is a covalently closed single-stranded RNA produced from pre-mRNAs via back-splicing reaction, an alternative form of splicing. Here, we show naphthyridine carbamate dimer (NCD) upregulating the production of a circRNA from a pre-mRNA containing NCD-binding site UGGAA/UGGAA in cells, demonstrating the feasibility of small-molecule mediated circRNA production.

Original language	English
Pages (from-to)	3629-3632
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	22
DOIs	https://doi.org/10.1039/d1cc06936e
Publication status	Published - Feb 24 2022
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d1cc06936e

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abstract = "Circular RNA (circRNA) is a covalently closed single-stranded RNA produced from pre-mRNAs via back-splicing reaction, an alternative form of splicing. Here, we show naphthyridine carbamate dimer (NCD) upregulating the production of a circRNA from a pre-mRNA containing NCD-binding site UGGAA/UGGAA in cells, demonstrating the feasibility of small-molecule mediated circRNA production.",

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AB - Circular RNA (circRNA) is a covalently closed single-stranded RNA produced from pre-mRNAs via back-splicing reaction, an alternative form of splicing. Here, we show naphthyridine carbamate dimer (NCD) upregulating the production of a circRNA from a pre-mRNA containing NCD-binding site UGGAA/UGGAA in cells, demonstrating the feasibility of small-molecule mediated circRNA production.

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Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model

Abstract

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