Abstract
Mitochondria, dynamic organelles that undergo continuous cycles of fusion and fission, are the powerhouses of eukaryotic cells. Recent research indicates that mitochondria also act as platforms for antiviral immunity in vertebrates. Mitochondrial-mediated antiviral immunity depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway and the participation of the mitochondrial outer membrane adaptor protein "mitochondrial antiviral signaling (MAVS)". Here we discuss recent findings that suggest how mitochondria contribute to antiviral innate immunity.
| Original language | English |
|---|---|
| Pages (from-to) | 257-262 |
| Number of pages | 6 |
| Journal | International Journal of Biochemistry and Molecular Biology |
| Volume | 2 |
| Issue number | 3 |
| Publication status | Published - Dec 1 2011 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Molecular Biology
Cite this
Mitochondria and antiviral innate immunity. / Koshiba, Takumi; Bashiruddin, Nasir; Kawabata, Shunichiro.
In: International Journal of Biochemistry and Molecular Biology, Vol. 2, No. 3, 01.12.2011, p. 257-262.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Mitochondria and antiviral innate immunity
AU - Koshiba, Takumi
AU - Bashiruddin, Nasir
AU - Kawabata, Shunichiro
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Mitochondria, dynamic organelles that undergo continuous cycles of fusion and fission, are the powerhouses of eukaryotic cells. Recent research indicates that mitochondria also act as platforms for antiviral immunity in vertebrates. Mitochondrial-mediated antiviral immunity depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway and the participation of the mitochondrial outer membrane adaptor protein "mitochondrial antiviral signaling (MAVS)". Here we discuss recent findings that suggest how mitochondria contribute to antiviral innate immunity.
AB - Mitochondria, dynamic organelles that undergo continuous cycles of fusion and fission, are the powerhouses of eukaryotic cells. Recent research indicates that mitochondria also act as platforms for antiviral immunity in vertebrates. Mitochondrial-mediated antiviral immunity depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway and the participation of the mitochondrial outer membrane adaptor protein "mitochondrial antiviral signaling (MAVS)". Here we discuss recent findings that suggest how mitochondria contribute to antiviral innate immunity.
UR - http://www.scopus.com/inward/record.url?scp=84855958148&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855958148&partnerID=8YFLogxK
M3 - Review article
C2 - 22003438
AN - SCOPUS:84855958148
VL - 2
SP - 257
EP - 262
JO - International Journal of Biochemistry and Molecular Biology
JF - International Journal of Biochemistry and Molecular Biology
SN - 2152-4114
IS - 3
ER -