Mitochondria and antiviral innate immunity

Takumi Koshiba, Nasir Bashiruddin, Shunichiro Kawabata

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Mitochondria, dynamic organelles that undergo continuous cycles of fusion and fission, are the powerhouses of eukaryotic cells. Recent research indicates that mitochondria also act as platforms for antiviral immunity in vertebrates. Mitochondrial-mediated antiviral immunity depends on activation of the retinoic acid-inducible gene I (RIG-I)-like receptors signal transduction pathway and the participation of the mitochondrial outer membrane adaptor protein "mitochondrial antiviral signaling (MAVS)". Here we discuss recent findings that suggest how mitochondria contribute to antiviral innate immunity.

Original languageEnglish
Pages (from-to)257-262
Number of pages6
JournalInternational Journal of Biochemistry and Molecular Biology
Volume2
Issue number3
Publication statusPublished - Dec 1 2011

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Mitochondria
Innate Immunity
Antiviral Agents
Immunity
Signal transduction
Mitochondrial Proteins
Eukaryotic Cells
Tretinoin
Organelles
Vertebrates
Signal Transduction
Membrane Proteins
Fusion reactions
Genes
Chemical activation
Membranes
Research

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

Mitochondria and antiviral innate immunity. / Koshiba, Takumi; Bashiruddin, Nasir; Kawabata, Shunichiro.

In: International Journal of Biochemistry and Molecular Biology, Vol. 2, No. 3, 01.12.2011, p. 257-262.

Research output: Contribution to journalReview article

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