Mitochondrial dynamics in exercise physiology

Tomohiro Tanaka, Akiyuki Nishimura, Kazuhiro Nishiyama, Takumi Goto, Takuro Numaga-Tomita, Motohiro Nishida

Research output: Contribution to journalReview article

Abstract

A growing body of evidence suggests that exercise shows pleiotropic effects on the maintenance of systemic homeostasis through mitochondria. Dysregulation of mitochondrial dynamism is associated with metabolic inflexibility, resulting in many of the metabolic diseases and aging. Studies have suggested that exercise prevents and delays the progression of mitochondrial dysfunction by improving mitochondrial metabolism, biogenesis, and quality control. Exercise modulates functions of mitochondrial dynamics-regulating proteins through post-translational modification mechanisms. In this review, we discuss the putative mechanisms underlying maintenance of mitochondrial homeostasis by exercise, especially focusing on the post-translational modifications of several signaling proteins contributing to mitochondrial biogenesis, autophagy or mitophagy flux, and fission/fusion cycle. We also introduce novel small molecules that can potentially mimic exercise therapy through preserving mitochondrial dynamism. These recent advancements in the field of mitochondrial biology may lead to a greater understanding of exercise signaling.

Original languageEnglish
JournalPflugers Archiv European Journal of Physiology
DOIs
Publication statusPublished - Jan 1 2019

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Mitochondrial Dynamics
Physiology
Organelle Biogenesis
Post Translational Protein Processing
Homeostasis
Mitochondrial Degradation
Maintenance
Exercise Therapy
Mitochondria
Metabolic Diseases
Autophagy
Metabolism
Quality Control
Quality control
Proteins
Fusion reactions
Aging of materials
Fluxes
Molecules

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

Cite this

Mitochondrial dynamics in exercise physiology. / Tanaka, Tomohiro; Nishimura, Akiyuki; Nishiyama, Kazuhiro; Goto, Takumi; Numaga-Tomita, Takuro; Nishida, Motohiro.

In: Pflugers Archiv European Journal of Physiology, 01.01.2019.

Research output: Contribution to journalReview article

Tanaka, Tomohiro ; Nishimura, Akiyuki ; Nishiyama, Kazuhiro ; Goto, Takumi ; Numaga-Tomita, Takuro ; Nishida, Motohiro. / Mitochondrial dynamics in exercise physiology. In: Pflugers Archiv European Journal of Physiology. 2019.
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