Mitochondrial physiology and cerebrospinal protection

Morika Suzuki, Hiroki Kato, Naomi Hachiya

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mitochondria maintain their numbers by the fusion and fission of preexisting mitochondria. Continuous mitochondrial fusion mixes the compartments, whereas fission segregates morphologically and functionally damaged mitochondria. This changing of their shape allows mitochondria to control the life and death processes of cells, such as apoptosis, the maintenance of cellular homeostasis, and ultimately the processes that occur in neurological disorders and metabolic diseases. GTPase family proteins and their regulators modulate the fusion/fission events, and a type of autophagy known as mitophagy removes damaged mitochondria. Although the molecular mechanistic effects of anesthetics on mitochondria are not yet clear, an enhanced understanding of this knowledge will be useful for the establishment of therapeutic approaches.

Original languageEnglish
Title of host publicationNeuroanesthesia and Cerebrospinal Protection
PublisherSpringer Japan
Pages63-70
Number of pages8
ISBN (Electronic)9784431544906
ISBN (Print)9784431544890
DOIs
Publication statusPublished - Aug 7 2015
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Suzuki, M., Kato, H., & Hachiya, N. (2015). Mitochondrial physiology and cerebrospinal protection. In Neuroanesthesia and Cerebrospinal Protection (pp. 63-70). Springer Japan. https://doi.org/10.1007/978-4-431-54490-6_6