Mitochondrial transcription factor a and mitochondrial genome as molecular targets for cisplatin-based cancer chemotherapy

Kimitoshi Kohno, Ke Yong Wang, Mayu Takahashi, Tomoko Kurita, Yoichiro Yoshida, Masakazu Hirakawa, Yoshikazu Harada, Akihiro Kuma, Hiroto Izumi, Shinji Matsumoto

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Mitochondria are important cellular organelles that function as control centers of the energy supply for highly proliferative cancer cells and regulate apoptosis after cancer chemotherapy. Cisplatin is one of the most important chemotherapeutic agents and a key drug in therapeutic regimens for a broad range of solid tumors. Cisplatin may directly interact with mitochondria, which can induce apoptosis. The direct interactions between cisplatin and mitochondria may account for our understanding of the clinical activity of cisplatin and development of resistance. However, the basis for the roles of mitochondria under treatment with chemotherapy is poorly understood. In this review, we present novel aspects regarding the unique characteristics of the mitochondrial genome in relation to the use of platinum-based chemotherapy and describe our recent work demonstrating the importance of the mitochondrial transcription factor A (mtTFA) expression in cancer cells.

Original languageEnglish
Pages (from-to)19836-19850
Number of pages15
JournalInternational journal of molecular sciences
Volume16
Issue number8
DOIs
Publication statusPublished - Aug 20 2015

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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  • Cite this

    Kohno, K., Wang, K. Y., Takahashi, M., Kurita, T., Yoshida, Y., Hirakawa, M., Harada, Y., Kuma, A., Izumi, H., & Matsumoto, S. (2015). Mitochondrial transcription factor a and mitochondrial genome as molecular targets for cisplatin-based cancer chemotherapy. International journal of molecular sciences, 16(8), 19836-19850. https://doi.org/10.3390/ijms160819836