Abstract
A growing body of evidence suggests that mammalian mitochondrial DNA takes on higher structure called nucleoid or mitochromosome corresponding to that of nuclear DNA. Mitochondrial transcription factor A (TFAM), which was cloned as a transcription factor for mitochondrial DNA, has known to be essential for the maintenance of mitochondrial DNA. Human TFAM has an ability to bind to DNA in a sequence-independent manner and is abundant enough to cover whole region of mitochondrial DNA, owing to which TFAM stabilizes mitochondrial DNA through formation of nucleoid and regulates (or titrates) the amount of mitochondrial DNA. Overexpression of human TFAM in mice increases the amount of mitochondrial DNA and dramatically ameliorates the cardiac dysfunctions caused by myocardial infarction. The maintenance of integrity of mitochondrial DNA is important for keeping proper cellular functions both under physiological and pathological conditions. TFAM may play a crucial role in maintaining mitochondrial DNA as a main component of the nucleoid.
| Original language | English |
|---|---|
| Pages (from-to) | 39-44 |
| Number of pages | 6 |
| Journal | Mitochondrion |
| Volume | 7 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Feb 1 2007 |
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All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Molecular Biology
- Cell Biology
Cite this
Mitochondrial transcription factor A (TFAM) : Roles in maintenance of mtDNA and cellular functions. / Kang, Dongchon; Kim, Sang Ho; Hamasaki, Naotaka.
In: Mitochondrion, Vol. 7, No. 1-2, 01.02.2007, p. 39-44.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Mitochondrial transcription factor A (TFAM)
T2 - Roles in maintenance of mtDNA and cellular functions
AU - Kang, Dongchon
AU - Kim, Sang Ho
AU - Hamasaki, Naotaka
PY - 2007/2/1
Y1 - 2007/2/1
N2 - A growing body of evidence suggests that mammalian mitochondrial DNA takes on higher structure called nucleoid or mitochromosome corresponding to that of nuclear DNA. Mitochondrial transcription factor A (TFAM), which was cloned as a transcription factor for mitochondrial DNA, has known to be essential for the maintenance of mitochondrial DNA. Human TFAM has an ability to bind to DNA in a sequence-independent manner and is abundant enough to cover whole region of mitochondrial DNA, owing to which TFAM stabilizes mitochondrial DNA through formation of nucleoid and regulates (or titrates) the amount of mitochondrial DNA. Overexpression of human TFAM in mice increases the amount of mitochondrial DNA and dramatically ameliorates the cardiac dysfunctions caused by myocardial infarction. The maintenance of integrity of mitochondrial DNA is important for keeping proper cellular functions both under physiological and pathological conditions. TFAM may play a crucial role in maintaining mitochondrial DNA as a main component of the nucleoid.
AB - A growing body of evidence suggests that mammalian mitochondrial DNA takes on higher structure called nucleoid or mitochromosome corresponding to that of nuclear DNA. Mitochondrial transcription factor A (TFAM), which was cloned as a transcription factor for mitochondrial DNA, has known to be essential for the maintenance of mitochondrial DNA. Human TFAM has an ability to bind to DNA in a sequence-independent manner and is abundant enough to cover whole region of mitochondrial DNA, owing to which TFAM stabilizes mitochondrial DNA through formation of nucleoid and regulates (or titrates) the amount of mitochondrial DNA. Overexpression of human TFAM in mice increases the amount of mitochondrial DNA and dramatically ameliorates the cardiac dysfunctions caused by myocardial infarction. The maintenance of integrity of mitochondrial DNA is important for keeping proper cellular functions both under physiological and pathological conditions. TFAM may play a crucial role in maintaining mitochondrial DNA as a main component of the nucleoid.
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UR - http://www.scopus.com/inward/citedby.url?scp=33847656213&partnerID=8YFLogxK
U2 - 10.1016/j.mito.2006.11.017
DO - 10.1016/j.mito.2006.11.017
M3 - Review article
C2 - 17280879
AN - SCOPUS:33847656213
VL - 7
SP - 39
EP - 44
JO - Mitochondrion
JF - Mitochondrion
SN - 1567-7249
IS - 1-2
ER -