Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes

Non-mitogen PL-D1 and mitogen PL-D2

Kenichi Yamaguchi, Mizuki Uechi, Yoshinori Katakura, Tatsuya Oda, Masatsune Ishiguro

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We investigated native structures and mitogenic properties of pokeweed lectin-D isoforms (PL-D1 and -D2) on human peripheral blood lymphocytes along with other isolectins (PL-A to -C). Both native PL-D isoforms appeared to behave as monomers. PL-D2 proliferated the lymphocytes like PL-C, whereas PL-D1 had no mitogenicity. PL-D1 acquired mitogenic activity after trimming of the C-terminal dipeptide.

Original languageEnglish
Pages (from-to)1591-1593
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume68
Issue number7
DOIs
Publication statusPublished - Jul 1 2004

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Phytolacca americana
Lymphocytes
Mitogens
lectins
Protein Isoforms
Blood
lymphocytes
dipeptides
Trimming
Dipeptides
blood
Lectins
Monomers
pokeweed lectin D

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes : Non-mitogen PL-D1 and mitogen PL-D2. / Yamaguchi, Kenichi; Uechi, Mizuki; Katakura, Yoshinori; Oda, Tatsuya; Ishiguro, Masatsune.

In: Bioscience, Biotechnology and Biochemistry, Vol. 68, No. 7, 01.07.2004, p. 1591-1593.

Research output: Contribution to journalArticle

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