Abstract
We investigated native structures and mitogenic properties of pokeweed lectin-D isoforms (PL-D1 and -D2) on human peripheral blood lymphocytes along with other isolectins (PL-A to -C). Both native PL-D isoforms appeared to behave as monomers. PL-D2 proliferated the lymphocytes like PL-C, whereas PL-D1 had no mitogenicity. PL-D1 acquired mitogenic activity after trimming of the C-terminal dipeptide.
| Original language | English |
|---|---|
| Pages (from-to) | 1591-1593 |
| Number of pages | 3 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 68 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 1 2004 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
Cite this
Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes : Non-mitogen PL-D1 and mitogen PL-D2. / Yamaguchi, Kenichi; Uechi, Mizuki; Katakura, Yoshinori; Oda, Tatsuya; Ishiguro, Masatsune.
In: Bioscience, Biotechnology and Biochemistry, Vol. 68, No. 7, 01.07.2004, p. 1591-1593.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes
T2 - Non-mitogen PL-D1 and mitogen PL-D2
AU - Yamaguchi, Kenichi
AU - Uechi, Mizuki
AU - Katakura, Yoshinori
AU - Oda, Tatsuya
AU - Ishiguro, Masatsune
PY - 2004/7/1
Y1 - 2004/7/1
N2 - We investigated native structures and mitogenic properties of pokeweed lectin-D isoforms (PL-D1 and -D2) on human peripheral blood lymphocytes along with other isolectins (PL-A to -C). Both native PL-D isoforms appeared to behave as monomers. PL-D2 proliferated the lymphocytes like PL-C, whereas PL-D1 had no mitogenicity. PL-D1 acquired mitogenic activity after trimming of the C-terminal dipeptide.
AB - We investigated native structures and mitogenic properties of pokeweed lectin-D isoforms (PL-D1 and -D2) on human peripheral blood lymphocytes along with other isolectins (PL-A to -C). Both native PL-D isoforms appeared to behave as monomers. PL-D2 proliferated the lymphocytes like PL-C, whereas PL-D1 had no mitogenicity. PL-D1 acquired mitogenic activity after trimming of the C-terminal dipeptide.
UR - http://www.scopus.com/inward/record.url?scp=11244313890&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11244313890&partnerID=8YFLogxK
U2 - 10.1271/bbb.68.1591
DO - 10.1271/bbb.68.1591
M3 - Article
C2 - 15277769
AN - SCOPUS:11244313890
VL - 68
SP - 1591
EP - 1593
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 7
ER -