Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes: Non-mitogen PL-D1 and mitogen PL-D2

Kenichi Yamaguchi; Mizuki Uechi; Yoshinori Katakura; Tatsuya Oda; Masatsune Ishiguro

doi:10.1271/bbb.68.1591

Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes: Non-mitogen PL-D1 and mitogen PL-D2

Kenichi Yamaguchi, Mizuki Uechi, Yoshinori Katakura, Tatsuya Oda, Masatsune Ishiguro

Systems Biology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We investigated native structures and mitogenic properties of pokeweed lectin-D isoforms (PL-D1 and -D2) on human peripheral blood lymphocytes along with other isolectins (PL-A to -C). Both native PL-D isoforms appeared to behave as monomers. PL-D2 proliferated the lymphocytes like PL-C, whereas PL-D1 had no mitogenicity. PL-D1 acquired mitogenic activity after trimming of the C-terminal dipeptide.

Original language	English
Pages (from-to)	1591-1593
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	68
Issue number	7
DOIs	https://doi.org/10.1271/bbb.68.1591
Publication status	Published - Jul 2004

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes : Non-mitogen PL-D1 and mitogen PL-D2. / Yamaguchi, Kenichi; Uechi, Mizuki; Katakura, Yoshinori; Oda, Tatsuya; Ishiguro, Masatsune.

In: Bioscience, Biotechnology and Biochemistry, Vol. 68, No. 7, 07.2004, p. 1591-1593.

Research output: Contribution to journal › Article › peer-review

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Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes: Non-mitogen PL-D1 and mitogen PL-D2

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