Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes: Non-mitogen PL-D1 and mitogen PL-D2

Kenichi Yamaguchi; Mizuki Uechi; Yoshinori Katakura; Tatsuya Oda; Masatsune Ishiguro

doi:10.1271/bbb.68.1591

Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes: Non-mitogen PL-D1 and mitogen PL-D2

Kenichi Yamaguchi, Mizuki Uechi, Yoshinori Katakura, Tatsuya Oda, Masatsune Ishiguro

Systems Biology

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We investigated native structures and mitogenic properties of pokeweed lectin-D isoforms (PL-D1 and -D2) on human peripheral blood lymphocytes along with other isolectins (PL-A to -C). Both native PL-D isoforms appeared to behave as monomers. PL-D2 proliferated the lymphocytes like PL-C, whereas PL-D1 had no mitogenicity. PL-D1 acquired mitogenic activity after trimming of the C-terminal dipeptide.

Original language	English
Pages (from-to)	1591-1593
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	68
Issue number	7
DOIs	https://doi.org/10.1271/bbb.68.1591
Publication status	Published - Jul 2004

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

Access to Document

10.1271/bbb.68.1591

Cite this

@article{7872764bef6f42d8be99786ad3a28b28,

title = "Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes: Non-mitogen PL-D1 and mitogen PL-D2",

abstract = "We investigated native structures and mitogenic properties of pokeweed lectin-D isoforms (PL-D1 and -D2) on human peripheral blood lymphocytes along with other isolectins (PL-A to -C). Both native PL-D isoforms appeared to behave as monomers. PL-D2 proliferated the lymphocytes like PL-C, whereas PL-D1 had no mitogenicity. PL-D1 acquired mitogenic activity after trimming of the C-terminal dipeptide.",

author = "Kenichi Yamaguchi and Mizuki Uechi and Yoshinori Katakura and Tatsuya Oda and Masatsune Ishiguro",

year = "2004",

month = jul,

doi = "10.1271/bbb.68.1591",

language = "English",

volume = "68",

pages = "1591--1593",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

number = "7",

}

TY - JOUR

T1 - Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes

T2 - Non-mitogen PL-D1 and mitogen PL-D2

AU - Yamaguchi, Kenichi

AU - Uechi, Mizuki

AU - Katakura, Yoshinori

AU - Oda, Tatsuya

AU - Ishiguro, Masatsune

PY - 2004/7

Y1 - 2004/7

N2 - We investigated native structures and mitogenic properties of pokeweed lectin-D isoforms (PL-D1 and -D2) on human peripheral blood lymphocytes along with other isolectins (PL-A to -C). Both native PL-D isoforms appeared to behave as monomers. PL-D2 proliferated the lymphocytes like PL-C, whereas PL-D1 had no mitogenicity. PL-D1 acquired mitogenic activity after trimming of the C-terminal dipeptide.

AB - We investigated native structures and mitogenic properties of pokeweed lectin-D isoforms (PL-D1 and -D2) on human peripheral blood lymphocytes along with other isolectins (PL-A to -C). Both native PL-D isoforms appeared to behave as monomers. PL-D2 proliferated the lymphocytes like PL-C, whereas PL-D1 had no mitogenicity. PL-D1 acquired mitogenic activity after trimming of the C-terminal dipeptide.

UR - http://www.scopus.com/inward/record.url?scp=11244313890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11244313890&partnerID=8YFLogxK

U2 - 10.1271/bbb.68.1591

DO - 10.1271/bbb.68.1591

M3 - Article

C2 - 15277769

AN - SCOPUS:11244313890

VL - 68

SP - 1591

EP - 1593

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 7

ER -

Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes: Non-mitogen PL-D1 and mitogen PL-D2

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this