Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes: Non-mitogen PL-D1 and mitogen PL-D2

Kenichi Yamaguchi, Mizuki Uechi, Yoshinori Katakura, Tatsuya Oda, Masatsune Ishiguro

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We investigated native structures and mitogenic properties of pokeweed lectin-D isoforms (PL-D1 and -D2) on human peripheral blood lymphocytes along with other isolectins (PL-A to -C). Both native PL-D isoforms appeared to behave as monomers. PL-D2 proliferated the lymphocytes like PL-C, whereas PL-D1 had no mitogenicity. PL-D1 acquired mitogenic activity after trimming of the C-terminal dipeptide.

Original languageEnglish
Pages (from-to)1591-1593
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume68
Issue number7
DOIs
Publication statusPublished - Jul 2004

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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