Abstract
We investigated native structures and mitogenic properties of pokeweed lectin-D isoforms (PL-D1 and -D2) on human peripheral blood lymphocytes along with other isolectins (PL-A to -C). Both native PL-D isoforms appeared to behave as monomers. PL-D2 proliferated the lymphocytes like PL-C, whereas PL-D1 had no mitogenicity. PL-D1 acquired mitogenic activity after trimming of the C-terminal dipeptide.
| Original language | English |
|---|---|
| Pages (from-to) | 1591-1593 |
| Number of pages | 3 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 68 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Jul 2004 |
All Science Journal Classification (ASJC) codes
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
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Cite this
Yamaguchi, K., Uechi, M., Katakura, Y., Oda, T., & Ishiguro, M. (2004). Mitogenic properties of pokeweed lectin-D isoforms on human peripheral blood lymphocytes: Non-mitogen PL-D1 and mitogen PL-D2. Bioscience, Biotechnology and Biochemistry, 68(7), 1591-1593. https://doi.org/10.1271/bbb.68.1591