Mitral annular remodeling to treat functional mitral regurgitation: A pilot acute study in a canine model

Hideyuki Fumoto, Tohru Takaseya, Akira Shiose, Roberto M. Saraiva, Yoko Arakawa, Margaret Park, Santosh Rao, Raymond Dessoffy, Ji Feng Chen, Qun Zhou, Anthony Calabro, Michael Banbury, Kiyotaka Fukamachi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The aim of this study was to evaluate the feasibility and efficacy of the injection of a nonabsorbable substance into the base of the left ventricle (LV) to treat functional mitral regurgitation (MR). Methods: Tyramine-based hyaluronan hydrogel was injected into the base of the LV of the beating heart in a canine model of rapid ventricular pacing-induced functional MR (n = 4). The severity of MR was evaluated by epicardial echocardiography before and after hydrogel injection. Results: The injection improved MR grade from 3.4 ± 0.8 to 1.3 ± 0.5 (P = .006) without inducing hemodynamic instability or any evidence of myocardial ischemia. We noted significant decreases in the septal-lateral dimension at the mitral annulus (3.4 ± 0.4 cm to 2.9 ± 0.3 cm; P = .039) and MR volume (20.6 ± 7.3 mm3 to 5.2 ± 2.2 mm3; P = .044). Conclusions: A novel treatment consisting of hydrogel injection into the base of the LV between the 2 papillary muscles was found to be feasible and effective for reducing functional MR in a canine model.

Original languageEnglish
JournalHeart Surgery Forum
Volume13
Issue number4
DOIs
Publication statusPublished - Aug 1 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Cardiology and Cardiovascular Medicine

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