Abstract
A minicolumn is the smallest anatomical module in the cortical architecture, but it is still in debate whether it serves as functional units for cortical processing. In the rodent primary visual cortex (V1), neurons with different preferred orientations are mixed horizontally in a salt and pepper manner, but vertical functional organization was not examined. In this study, we found that neurons with similar orientation preference are weakly but significantly clustered vertically in a short length and horizontally in the scale of a minicolumn. Interestingly, the vertical clustering is found only in a part of minicolumns, and others are composed of neurons with a variety of orientation preferences. Thus, the mouse V1 is a mixture of vertical clusters of neurons with various degrees of orientation similarity, which may be the compromise between the brain size and keeping the vertical clusters of similarly tuned neurons at least in a subset of clusters.
| Original language | English |
|---|---|
| Article number | 13210 |
| Journal | Nature communications |
| Volume | 7 |
| DOIs | |
| Publication status | Published - Oct 21 2016 |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Physics and Astronomy(all)
Cite this
Mixed functional microarchitectures for orientation selectivity in the mouse primary visual cortex. / Kondo, Satoru; Yoshida, Takashi; Ohki, Kenichi.
In: Nature communications, Vol. 7, 13210, 21.10.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mixed functional microarchitectures for orientation selectivity in the mouse primary visual cortex
AU - Kondo, Satoru
AU - Yoshida, Takashi
AU - Ohki, Kenichi
PY - 2016/10/21
Y1 - 2016/10/21
N2 - A minicolumn is the smallest anatomical module in the cortical architecture, but it is still in debate whether it serves as functional units for cortical processing. In the rodent primary visual cortex (V1), neurons with different preferred orientations are mixed horizontally in a salt and pepper manner, but vertical functional organization was not examined. In this study, we found that neurons with similar orientation preference are weakly but significantly clustered vertically in a short length and horizontally in the scale of a minicolumn. Interestingly, the vertical clustering is found only in a part of minicolumns, and others are composed of neurons with a variety of orientation preferences. Thus, the mouse V1 is a mixture of vertical clusters of neurons with various degrees of orientation similarity, which may be the compromise between the brain size and keeping the vertical clusters of similarly tuned neurons at least in a subset of clusters.
AB - A minicolumn is the smallest anatomical module in the cortical architecture, but it is still in debate whether it serves as functional units for cortical processing. In the rodent primary visual cortex (V1), neurons with different preferred orientations are mixed horizontally in a salt and pepper manner, but vertical functional organization was not examined. In this study, we found that neurons with similar orientation preference are weakly but significantly clustered vertically in a short length and horizontally in the scale of a minicolumn. Interestingly, the vertical clustering is found only in a part of minicolumns, and others are composed of neurons with a variety of orientation preferences. Thus, the mouse V1 is a mixture of vertical clusters of neurons with various degrees of orientation similarity, which may be the compromise between the brain size and keeping the vertical clusters of similarly tuned neurons at least in a subset of clusters.
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U2 - 10.1038/ncomms13210
DO - 10.1038/ncomms13210
M3 - Article
AN - SCOPUS:84992388867
VL - 7
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 13210
ER -