Mode of death in patients with heart failure and reduced vs. preserved ejection fraction: - Report from the registry of hospitalized heart failure patients

Sanae Hamaguchi, Shintaro Kinugawa, Mochamad Ali Sobirin, Daisuke Goto, Miyuki Tsuchihashi-Makaya, Satoshi Yamada, Hisashi Yokoshiki, Hiroyuki Tsutsui

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Abstract

Background: The mode of death has not been investigated in the registry data of patients with heart failure and reduced ejection fraction (HFREF) vs. preserved ejection fraction (HFPEF). The aim of the present study was therefore to carry out this comparison. Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) prospectively studied the characteristics and treatments in a broad sample of 2,675 patients hospitalized with worsening HF, and followed them for an average of 2.1 years. This study included 323 patients in whom information on both the mode of death and left ventricular EF on echocardiography could be obtained. The mode of death was cardiovascular (CV) in 63% (including 17% sudden, 36% HF, 3% myocardial infarction, and 3% stroke), non-CV in 23%, and unknown in 14%. The prevalence of CV death including sudden death was high in patients with HFREF compared to HFPEF (68% vs. 58%, P=0.020). HF death, the most common mode of death, was similar between groups (37% vs. 35%, P=0.694). In contrast, non-CV mortality was significantly higher in HFPEF than those with HFREF (28% vs. 18%, P=0.021). Conclusions: In 60-70% of deaths the mode was CV, and HF death was the most common mode of death in either HFREF or HFPEF. The prevalence of sudden death was lower, and that of non-CV death higher, in HFPEF compared with HFREF.

Original languageEnglish
Pages (from-to)1662-1669
Number of pages8
JournalCirculation Journal
Volume76
Issue number7
DOIs
Publication statusPublished - Jul 5 2012
Externally publishedYes

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Registries
Heart Failure
Sudden Death
Myocardial Infarction
Cardiology
Echocardiography
Mortality

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Mode of death in patients with heart failure and reduced vs. preserved ejection fraction : - Report from the registry of hospitalized heart failure patients. / Hamaguchi, Sanae; Kinugawa, Shintaro; Sobirin, Mochamad Ali; Goto, Daisuke; Tsuchihashi-Makaya, Miyuki; Yamada, Satoshi; Yokoshiki, Hisashi; Tsutsui, Hiroyuki.

In: Circulation Journal, Vol. 76, No. 7, 05.07.2012, p. 1662-1669.

Research output: Contribution to journalArticle

Hamaguchi, Sanae ; Kinugawa, Shintaro ; Sobirin, Mochamad Ali ; Goto, Daisuke ; Tsuchihashi-Makaya, Miyuki ; Yamada, Satoshi ; Yokoshiki, Hisashi ; Tsutsui, Hiroyuki. / Mode of death in patients with heart failure and reduced vs. preserved ejection fraction : - Report from the registry of hospitalized heart failure patients. In: Circulation Journal. 2012 ; Vol. 76, No. 7. pp. 1662-1669.
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AU - Hamaguchi, Sanae

AU - Kinugawa, Shintaro

AU - Sobirin, Mochamad Ali

AU - Goto, Daisuke

AU - Tsuchihashi-Makaya, Miyuki

AU - Yamada, Satoshi

AU - Yokoshiki, Hisashi

AU - Tsutsui, Hiroyuki

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N2 - Background: The mode of death has not been investigated in the registry data of patients with heart failure and reduced ejection fraction (HFREF) vs. preserved ejection fraction (HFPEF). The aim of the present study was therefore to carry out this comparison. Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) prospectively studied the characteristics and treatments in a broad sample of 2,675 patients hospitalized with worsening HF, and followed them for an average of 2.1 years. This study included 323 patients in whom information on both the mode of death and left ventricular EF on echocardiography could be obtained. The mode of death was cardiovascular (CV) in 63% (including 17% sudden, 36% HF, 3% myocardial infarction, and 3% stroke), non-CV in 23%, and unknown in 14%. The prevalence of CV death including sudden death was high in patients with HFREF compared to HFPEF (68% vs. 58%, P=0.020). HF death, the most common mode of death, was similar between groups (37% vs. 35%, P=0.694). In contrast, non-CV mortality was significantly higher in HFPEF than those with HFREF (28% vs. 18%, P=0.021). Conclusions: In 60-70% of deaths the mode was CV, and HF death was the most common mode of death in either HFREF or HFPEF. The prevalence of sudden death was lower, and that of non-CV death higher, in HFPEF compared with HFREF.

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