Model study of CO inhibition of [NiFe]hydrogenase

Takahiro Matsumoto, Ryota Kabe, Kyoshiro Nonaka, Tatsuya Ando, Ki Seok Yoon, Hidetaka Nakai, Seiji Ogo

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

We propose a modified mechanism for the inhibition of [NiFe]hydrogenase ([NiFe]H 2ase) by CO. We present a model study, using a NiRu H 2ase mimic, that demonstrates that (i) CO completely inhibits the catalytic cycle of the model compound, (ii) CO prefers to coordinate to the Ru II center rather than taking an axial position on the Ni II center, and (iii) CO is unable to displace a hydrido ligand from the NiRu center. We combine these studies with a reevaluation of previous studies to propose that, under normal circumstances, CO inhibits [NiFe]H 2ase by complexing to the Fe II center.

Original languageEnglish
Pages (from-to)8902-8906
Number of pages5
JournalInorganic Chemistry
Volume50
Issue number18
DOIs
Publication statusPublished - Sep 19 2011

All Science Journal Classification (ASJC) codes

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

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