Modeling Lung Branching Morphogenesis

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Citations (Scopus)

Abstract

Vertebrate lung has tree-like structure which facilitates gas exchange. After discovery of the involvement of several key toolkit genes-FGF10, BMP4, and Shh, huge amount of molecular information on lung development is now available. However, how their interactions result in a branched structure has not been elucidated. Recently, some studies have utilized mathematical models to understand the mechanism of branching morphogenesis, and we now have some models which are reliable enough to make experimental predictions in the in vitro system. In addition, a different type of modeling, which generates tree-like branching pattern by repeatedly applying a set of simple rules iteratively, is also utilized to model lung function. In this review, I focus on how these models can contribute to understand pattern formation phenomena from experimental biologist's point of view.

Original languageEnglish
Title of host publicationMultiscale Modeling of Developmental Systems
EditorsSantiago Schnell, Philip Maini, Stuart Newman, Timothy Newman
Pages291-310
Number of pages20
DOIs
Publication statusPublished - Jan 1 2008

Publication series

NameCurrent Topics in Developmental Biology
Volume81
ISSN (Print)0070-2153

Fingerprint

Morphogenesis
Lung
Vertebrates
Theoretical Models
Gases
Genes

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

Cite this

Miura, T. (2008). Modeling Lung Branching Morphogenesis. In S. Schnell, P. Maini, S. Newman, & T. Newman (Eds.), Multiscale Modeling of Developmental Systems (pp. 291-310). (Current Topics in Developmental Biology; Vol. 81). https://doi.org/10.1016/S0070-2153(07)81010-6

Modeling Lung Branching Morphogenesis. / Miura, Takashi.

Multiscale Modeling of Developmental Systems. ed. / Santiago Schnell; Philip Maini; Stuart Newman; Timothy Newman. 2008. p. 291-310 (Current Topics in Developmental Biology; Vol. 81).

Research output: Chapter in Book/Report/Conference proceedingChapter

Miura, T 2008, Modeling Lung Branching Morphogenesis. in S Schnell, P Maini, S Newman & T Newman (eds), Multiscale Modeling of Developmental Systems. Current Topics in Developmental Biology, vol. 81, pp. 291-310. https://doi.org/10.1016/S0070-2153(07)81010-6
Miura T. Modeling Lung Branching Morphogenesis. In Schnell S, Maini P, Newman S, Newman T, editors, Multiscale Modeling of Developmental Systems. 2008. p. 291-310. (Current Topics in Developmental Biology). https://doi.org/10.1016/S0070-2153(07)81010-6
Miura, Takashi. / Modeling Lung Branching Morphogenesis. Multiscale Modeling of Developmental Systems. editor / Santiago Schnell ; Philip Maini ; Stuart Newman ; Timothy Newman. 2008. pp. 291-310 (Current Topics in Developmental Biology).
@inbook{470583f073e34c74b7325b96d650e99e,
title = "Modeling Lung Branching Morphogenesis",
abstract = "Vertebrate lung has tree-like structure which facilitates gas exchange. After discovery of the involvement of several key toolkit genes-FGF10, BMP4, and Shh, huge amount of molecular information on lung development is now available. However, how their interactions result in a branched structure has not been elucidated. Recently, some studies have utilized mathematical models to understand the mechanism of branching morphogenesis, and we now have some models which are reliable enough to make experimental predictions in the in vitro system. In addition, a different type of modeling, which generates tree-like branching pattern by repeatedly applying a set of simple rules iteratively, is also utilized to model lung function. In this review, I focus on how these models can contribute to understand pattern formation phenomena from experimental biologist's point of view.",
author = "Takashi Miura",
year = "2008",
month = "1",
day = "1",
doi = "10.1016/S0070-2153(07)81010-6",
language = "English",
isbn = "0123742536",
series = "Current Topics in Developmental Biology",
pages = "291--310",
editor = "Santiago Schnell and Philip Maini and Stuart Newman and Timothy Newman",
booktitle = "Multiscale Modeling of Developmental Systems",

}

TY - CHAP

T1 - Modeling Lung Branching Morphogenesis

AU - Miura, Takashi

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Vertebrate lung has tree-like structure which facilitates gas exchange. After discovery of the involvement of several key toolkit genes-FGF10, BMP4, and Shh, huge amount of molecular information on lung development is now available. However, how their interactions result in a branched structure has not been elucidated. Recently, some studies have utilized mathematical models to understand the mechanism of branching morphogenesis, and we now have some models which are reliable enough to make experimental predictions in the in vitro system. In addition, a different type of modeling, which generates tree-like branching pattern by repeatedly applying a set of simple rules iteratively, is also utilized to model lung function. In this review, I focus on how these models can contribute to understand pattern formation phenomena from experimental biologist's point of view.

AB - Vertebrate lung has tree-like structure which facilitates gas exchange. After discovery of the involvement of several key toolkit genes-FGF10, BMP4, and Shh, huge amount of molecular information on lung development is now available. However, how their interactions result in a branched structure has not been elucidated. Recently, some studies have utilized mathematical models to understand the mechanism of branching morphogenesis, and we now have some models which are reliable enough to make experimental predictions in the in vitro system. In addition, a different type of modeling, which generates tree-like branching pattern by repeatedly applying a set of simple rules iteratively, is also utilized to model lung function. In this review, I focus on how these models can contribute to understand pattern formation phenomena from experimental biologist's point of view.

UR - http://www.scopus.com/inward/record.url?scp=36148929782&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=36148929782&partnerID=8YFLogxK

U2 - 10.1016/S0070-2153(07)81010-6

DO - 10.1016/S0070-2153(07)81010-6

M3 - Chapter

C2 - 18023732

AN - SCOPUS:36148929782

SN - 0123742536

SN - 9780123742537

T3 - Current Topics in Developmental Biology

SP - 291

EP - 310

BT - Multiscale Modeling of Developmental Systems

A2 - Schnell, Santiago

A2 - Maini, Philip

A2 - Newman, Stuart

A2 - Newman, Timothy

ER -