TY - JOUR
T1 - Models of compensatory molecular evolution
T2 - Effects of back mutation
AU - Ichinose, Motoshi
AU - Iizuka, Masaru
AU - Kusumi, Junko
AU - Takefu, Masasuke
N1 - Funding Information:
We would like to thank two anonymous reviewers for their valuable comments, which improved the presentation of this work. M.I. was partially supported by Grant-in-Aid for Scientific Research (C) from Japan Society for the Promotion of Science Nos. 21540143 and 22540132 .
PY - 2013/4/1
Y1 - 2013/4/1
N2 - Compensatory mutations are individually deleterious but appropriate combinations of mutants are harmless. For several models of compensatory molecular evolution, we consider the effects of back mutation. It is shown that the effects of back mutation on the rate of compensatory molecular evolution are weak. Further we estimate the values of selection parameter of deleterious single mutants for the models of compensatory molecular evolution both with and without back mutation using sequence data of folded RNA molecules and compare them with the previous results.
AB - Compensatory mutations are individually deleterious but appropriate combinations of mutants are harmless. For several models of compensatory molecular evolution, we consider the effects of back mutation. It is shown that the effects of back mutation on the rate of compensatory molecular evolution are weak. Further we estimate the values of selection parameter of deleterious single mutants for the models of compensatory molecular evolution both with and without back mutation using sequence data of folded RNA molecules and compare them with the previous results.
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U2 - 10.1016/j.jtbi.2013.01.011
DO - 10.1016/j.jtbi.2013.01.011
M3 - Article
C2 - 23353018
AN - SCOPUS:84873564052
SN - 0022-5193
VL - 323
SP - 1
EP - 10
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
ER -