Models of lung branching morphogenesis

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Vertebrate airway has a tree-like-branched structure. This structure is generated by repeated tip splitting, which is called branching morphogenesis. Although this phenomenon is extensively studied in developmental biology, the mechanism of the pattern formation is not well understood. Conversely, there are many tree-like structures in purely physical or chemical systems, and their pattern formation mechanisms are well-understood using mathematical models. Recent studies correlate these biological observations and mathematical models to understand lung branching morphogenesis. These models use slightly different mechanisms. In this article, we will review recent progress in modelling lung branching morphogenesis, and future directions to experimentally verify the models.

Original languageEnglish
Pages (from-to)121-127
Number of pages7
JournalJournal of biochemistry
Volume157
Issue number3
DOIs
Publication statusPublished - Mar 1 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Fingerprint Dive into the research topics of 'Models of lung branching morphogenesis'. Together they form a unique fingerprint.

Cite this