TY - JOUR
T1 - Modification of glucocorticoid sensitivity by MAP kinase signaling pathways in glucocorticoid-induced T-cell apoptosis
AU - Tanaka, Tomoko
AU - Okabe, Taijiro
AU - Gondo, Shigeki
AU - Fukuda, Mitsue
AU - Yamamoto, Masahiro
AU - Umemura, Tsukuru
AU - Tani, Kenzaburo
AU - Nomura, Masatoshi
AU - Goto, Kiminobu
AU - Yanase, Toshihiko
AU - Nawata, Hajime
PY - 2006/11
Y1 - 2006/11
N2 - Objective: Glucocorticoid is widely used for the treatment of diseases such as hematological malignancies. Glucocorticoid sensitivity is different from person to person and the mechanism of the regulation of glucocorticoid sensitivity is not well known. Glucocorticoid resistance is a major clinical problem. Methods and Results: Here, using glucocorticoid-induced T-cell apoptosis, a model system for the analysis of the mechanism of glucocorticoid action, we clarified that mitogen-activated protein kinases (MAPKs) modify glucocorticoid sensitivity, namely that the activation of extracellular signal-regulated protein kinase (ERK) and p38 MAP kinase reduce and enhance glucocorticoid sensitivity, respectively. Conclusion: These findings might provide new tools for overcoming glucocorticoid-resistance.
AB - Objective: Glucocorticoid is widely used for the treatment of diseases such as hematological malignancies. Glucocorticoid sensitivity is different from person to person and the mechanism of the regulation of glucocorticoid sensitivity is not well known. Glucocorticoid resistance is a major clinical problem. Methods and Results: Here, using glucocorticoid-induced T-cell apoptosis, a model system for the analysis of the mechanism of glucocorticoid action, we clarified that mitogen-activated protein kinases (MAPKs) modify glucocorticoid sensitivity, namely that the activation of extracellular signal-regulated protein kinase (ERK) and p38 MAP kinase reduce and enhance glucocorticoid sensitivity, respectively. Conclusion: These findings might provide new tools for overcoming glucocorticoid-resistance.
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U2 - 10.1016/j.exphem.2006.06.018
DO - 10.1016/j.exphem.2006.06.018
M3 - Article
C2 - 17046574
AN - SCOPUS:33749640683
VL - 34
SP - 1542
EP - 1552
JO - Experimental Hematology
JF - Experimental Hematology
SN - 0301-472X
IS - 11
ER -