Modification of gold nanorods using phosphatidylcholine to reduce cytotoxicity

Hironobu Takahashi, Yasuro Niidome, Takuro Niidome, Kenji Kaneko, Hideya Kawasaki, Sunao Yamada

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Abstract

Hexadecyltrimethylammonium bromide (CTAB), which is necessary for the preparation of gold nanorods (NRs), was extracted from a NR solution into a chloroform phase containing phosphatidylcholine (PC). After three extractions, the zeta potential of the NRs remained positive, but its magnitude decreased from+67 ±1 to+15± 1 mV. Transmission electron microscopy and energy-dispersive X-ray analysis indicated that the NRs were passivated with PC. The PC layer on the NR surface contributed to the prevention of NR aggregation. The PC-passivated NRs showed low cytotoxicity in comparison with twice-centrifuged NRs. It was shown that a negligible amount of CTAB was dispersed in the NR solution after the extraction. The extraction using a chloroform phase containing PC was found to be a convenient way of replacing the CTAB with alternative capping agents such as PC. This is a key technique for preparing functional NRs that can have practical applications.

Original languageEnglish
Pages (from-to)2-5
Number of pages4
JournalLangmuir
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 3 2006

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Cite this

Takahashi, H., Niidome, Y., Niidome, T., Kaneko, K., Kawasaki, H., & Yamada, S. (2006). Modification of gold nanorods using phosphatidylcholine to reduce cytotoxicity. Langmuir, 22(1), 2-5. https://doi.org/10.1021/la0520029