Modification of neuropathic pain sensation through microglial ATP receptors

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Neuropathic pain that typically develops when peripheral nerves are damaged through surgery, bone compression in cancer, diabetes, or infection is a major factor causing impaired quality of life in millions of people worldwide. Recently, there has been a rapidly growing body of evidence indicating that spinal glia play a critical role in the pathogenesis of neuropathic pain. Accumulating findings also indicate that nucleotides play an important role in neuron-glia communication through P2 purinoceptors. Damaged neurons release or leak nucleotides including ATP and UTP to stimulate microglia through P2 purinoceptors expressing on microglia. It was shown in an animal model of neuropathic pain that microglial P2X4 and P2X7 receptors are crucial in pain signaling after peripheral nerve lesion. In this review, we describe the modification of neuropathic pain sensation through microglial P2X4 and P2X7, with the possibility of P2Y6 and P2Y12 involvement.

Original languageEnglish
Pages (from-to)311-316
Number of pages6
JournalPurinergic Signalling
Volume3
Issue number4
DOIs
Publication statusPublished - Sep 1 2007

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Purinergic P2 Receptors
Neuralgia
Microglia
Peripheral Nerves
Neuroglia
Purinergic P2X4 Receptors
Nucleotides
Purinergic P2X7 Receptors
Neurons
Uridine Triphosphate
Animal Models
Adenosine Triphosphate
Communication
Quality of Life
Bone and Bones
Pain
Infection
Neoplasms

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Modification of neuropathic pain sensation through microglial ATP receptors. / Inoue, Kazuhide; Makoto, Tsuda; Saitoh, Hidetoshi.

In: Purinergic Signalling, Vol. 3, No. 4, 01.09.2007, p. 311-316.

Research output: Contribution to journalReview article

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