Modified cyclization of enantio-enriched α-homoallyloxyalkyllithiums generated by Sn-Li transmetallation: Effects of additives and structural requirement

Nobuyuki Komine, Katsuhiko Tomooka, Takeshi Nakai

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The titled cyclization, when performed in the presence of lithium chloride, afforded an improved yield of the enantio-enriched 2,3-trans- disubstituted tetrahydrofuran derivative in high diastereoselectivity, whereas a similar cyclization in the presence of zinc bromide gave the 2,3- cis isomer as the major product in lower enantiopurity.

Original languageEnglish
Pages (from-to)1071-1074
Number of pages4
JournalHeterocycles
Volume52
Issue number3
Publication statusPublished - Mar 1 2000
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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