Modulation of a N-nitrosobis(2-hydroxypropyl)amine-induced carcinogenesis by clofibrate in hamsters

Kazuhiro Mizumoto, Shunji Kitazawa, Toru Eguchi, Akira Nakajima, Masahiro Tsutsmi, Shinichi Ito, Ayumi Danda, Yoichi Konishi

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The effects of clofibrate treatment on N-nitrosobis(2-hydroxy-propyl)amine (BHP) induced liver, gall bladder, pancreas, lung and kidney carcinogenesis in hamsters were studied. Animals were given BHP as an initiator at a dose of 500 mg/kg body weight subcutaneously once a week for 5 weeks followed by diet containing 0.25 or 0.5% clofibrate for 30 weeks. Both doses of clofibrate promoted hepatocarcino-genesis as judged from the associated multiplicity of liver lesions including hyperplastic nodules and hepatocellular carcinomas. γ-Glutamyltranspeptidase (γ-GTP) activity was not expressed in those lesions in the liver of hamsters given BHP followed by a basal diet or diets containing clofibrate. Clofibrate at a dose of 0.5% in the diet, in contrast, inhibited the development of pancreatic adenocarcinomas and lung neoplasms, including adenomas and adenocarcinomas, without affecting carcinogenesis in the gall bladder and kidney. These results clearly indicate differectial modification potential of clofibrate for BHP-induced liver, pancreas and lung carcinogenesis in Syrian hamsters.

Original languageEnglish
Pages (from-to)1421-1425
Number of pages5
JournalCarcinogenesis
Volume9
Issue number8
DOIs
Publication statusPublished - Aug 1 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cancer Research

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