Modulation of ATP-induced inward currents by docosahexaenoic acid and other fatty acids in rat nodose ganglion neurons

Kei Eto, Yukiko Arimura, Hiroko Mizuguchi, Masazumi Nishikawa, Mami Noda, Hitoshi Ishibashi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The effects of docosahexaenoic acid (DHA) and other fatty acids on P2X-receptor-mediated inward currents in rat nodose ganglion neurons were studied using the nystatin perforated patch-clamp technique. DHA accelerated the desensitization rate of the ATP-induced current. DHA showed use-dependent inhibition of the peak ATP-induced current. Other polyunsaturated fatty acids, such as arachidonic acid and eicosapentaenoic acid, displayed a similar use-dependent inhibition. The inhibitory effects of saturated fatty acids including palmitic acid and arachidic acid were weaker than those of polyunsaturated fatty acids. The results suggest that fatty acids may modulate the P2X receptor-mediated response when the channel is in the open-state.

Original languageEnglish
Pages (from-to)343-346
Number of pages4
JournalJournal of Pharmacological Sciences
Volume102
Issue number3
DOIs
Publication statusPublished - 2006

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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