Modulation of cytotoxic effect of anticancer drugs by dipyridamole in HeLa cells in vitro

H. Kusumoto, Yoshihiko Maehara, Y. Sakaguchi, S. Kohnoe, R. Kumashiro, K. Sugimachi

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Abstract

Exponentially growing HeLa cells were treated with various antitumor drugs and dipyridamole (DP), and the cell growth inhibition ratio was determined. Enhanced growth inhibition was found in combined treatment with DP and 5-fluorouracil, 1-hexylcarbamoyl-5-fluorouracil, methotrexate, adriamycin, daunomycin, 4'-0-tetrahydropyranyladriamycin, actinomycin D and vincristine. In contrast, reduction of the cytotoxic effect of cytosine arabinoside and enocitabine was found when these were combined with DP.

Original languageEnglish
Pages (from-to)1643-1645
Number of pages3
JournalAnticancer research
Volume10
Issue number6
Publication statusPublished - Dec 1 1990

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Kusumoto, H., Maehara, Y., Sakaguchi, Y., Kohnoe, S., Kumashiro, R., & Sugimachi, K. (1990). Modulation of cytotoxic effect of anticancer drugs by dipyridamole in HeLa cells in vitro. Anticancer research, 10(6), 1643-1645.