Abstract
and acts as a decoy receptor in the RANK-RANKL signaling system (Fig. 8). In conclusion, osteoblasts/stromal cells are involved in all of the processes of osteoclast development, such as differentiation, survival, fusion, and activation of osteoclasts (Fig. 8). Osteoblasts/stromal cells can now be replaced with RANKL and M-CSF in dealing with the whole life of osteoclasts. RANKL, RANK, and OPG are three key molecules that regulate osteoclast recruitment and function. Further studies on these key molecules will elucidate the molecular mechanism of the regulation of osteoclastic bone resorption. This line of studies will establish new ways to treat several metabolic bone diseases caused by abnormal osteoclast recruitment and functions such as osteopetrosis, osteoporosis, metastatic bone disease, Paget's disease, rheumatoid arthritis, and periodontal bone disease.
| Original language | English |
|---|---|
| Pages (from-to) | 345-357 |
| Number of pages | 13 |
| Journal | Endocrine Reviews |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jan 1 1999 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Endocrinology
Cite this
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. / Suda, T.; Takahashi, N.; Udagawa, N.; Jimi, E.; Gillespie, M. T.; Martin, T. J.
In: Endocrine Reviews, Vol. 20, No. 3, 01.01.1999, p. 345-357.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
AU - Suda, T.
AU - Takahashi, N.
AU - Udagawa, N.
AU - Jimi, E.
AU - Gillespie, M. T.
AU - Martin, T. J.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - and acts as a decoy receptor in the RANK-RANKL signaling system (Fig. 8). In conclusion, osteoblasts/stromal cells are involved in all of the processes of osteoclast development, such as differentiation, survival, fusion, and activation of osteoclasts (Fig. 8). Osteoblasts/stromal cells can now be replaced with RANKL and M-CSF in dealing with the whole life of osteoclasts. RANKL, RANK, and OPG are three key molecules that regulate osteoclast recruitment and function. Further studies on these key molecules will elucidate the molecular mechanism of the regulation of osteoclastic bone resorption. This line of studies will establish new ways to treat several metabolic bone diseases caused by abnormal osteoclast recruitment and functions such as osteopetrosis, osteoporosis, metastatic bone disease, Paget's disease, rheumatoid arthritis, and periodontal bone disease.
AB - and acts as a decoy receptor in the RANK-RANKL signaling system (Fig. 8). In conclusion, osteoblasts/stromal cells are involved in all of the processes of osteoclast development, such as differentiation, survival, fusion, and activation of osteoclasts (Fig. 8). Osteoblasts/stromal cells can now be replaced with RANKL and M-CSF in dealing with the whole life of osteoclasts. RANKL, RANK, and OPG are three key molecules that regulate osteoclast recruitment and function. Further studies on these key molecules will elucidate the molecular mechanism of the regulation of osteoclastic bone resorption. This line of studies will establish new ways to treat several metabolic bone diseases caused by abnormal osteoclast recruitment and functions such as osteopetrosis, osteoporosis, metastatic bone disease, Paget's disease, rheumatoid arthritis, and periodontal bone disease.
UR - http://www.scopus.com/inward/record.url?scp=0033304730&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033304730&partnerID=8YFLogxK
U2 - 10.1210/edrv.20.3.0367
DO - 10.1210/edrv.20.3.0367
M3 - Review article
C2 - 10368775
AN - SCOPUS:0033304730
VL - 20
SP - 345
EP - 357
JO - Endocrine Reviews
JF - Endocrine Reviews
SN - 0163-769X
IS - 3
ER -