Modulation of Pain and Itch by Spinal Glia

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Chronic pain and itch are a pathological operation of the somatosensory system at the levels of primary sensory neurons, spinal cord and brain. Pain and itch are clearly distinct sensations, and recent studies have revealed the separate neuronal pathways that are involved in each sensation. However, the mechanisms by which these sensations turn into a pathological chronic state are poorly understood. A proposed mechanism underlying chronic pain and itch involves abnormal excitability in dorsal horn neurons in the spinal cord. Furthermore, an increasing body of evidence from models of chronic pain and itch has indicated that synaptic hyperexcitability in the spinal dorsal horn might not be a consequence simply of changes in neurons, but rather of multiple alterations in glial cells. Thus, understanding the key roles of glial cells may provide us with exciting insights into the mechanisms of chronicity of pain and itch, and lead to new targets for treating chronic pain and itch.

Original languageEnglish
Pages (from-to)178-185
Number of pages8
JournalNeuroscience Bulletin
Volume34
Issue number1
DOIs
Publication statusPublished - Feb 1 2018

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Neuroglia
Chronic Pain
Pain
Spinal Cord
Posterior Horn Cells
Sensory Receptor Cells
Neurons
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Physiology

Cite this

Modulation of Pain and Itch by Spinal Glia. / Makoto, Tsuda.

In: Neuroscience Bulletin, Vol. 34, No. 1, 01.02.2018, p. 178-185.

Research output: Contribution to journalReview article

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