Abstract
The topical application of quercetin, an anti-tumor promoter, to mouse skin reduced the number of phorbol ester receptors, although quercetin did not inhibit specific 3H12-O-tetradecanoylphorbol-13-acetate binding to a mouse skin particulate fraction. Quercetin, morin, kaempferol and luteolin inhibited activation of protein kinase C by teleocidin, and caused half-maximal activation at 25μM (+)-Catechin, which has been reported not to inhibit tumor-promoting activity, did not have any effect on these reactions. The modulation of phorbol ester receptors and inhibition of activation of protein kinase C are considered to be involved in the anti-tumor-pro-moting effect of quercetin in mouse skin. Diet containing 4% or 1% quercetin did not influence the action of teleocidin on mouse skin in a two-stage carcinogenesis experi-ment.
Original language | English |
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Pages (from-to) | 526-531 |
Number of pages | 6 |
Journal | Japanese Journal of Cancer Research GANN |
Volume | 77 |
Issue number | 6 |
Publication status | Published - Jan 1 1986 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Oncology
- Cancer Research