Modulation of phorbol ester receptors in mouse skin by application of quercetin

Takahiko Horiuchi, Hirota Fujiki, Hiromi Hakii, Masami Suganuma, Katsumi Yamashita, Takashi Sugimura

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Abstract

The topical application of quercetin, an anti-tumor promoter, to mouse skin reduced the number of phorbol ester receptors, although quercetin did not inhibit specific 3H12-O-tetradecanoylphorbol-13-acetate binding to a mouse skin particulate fraction. Quercetin, morin, kaempferol and luteolin inhibited activation of protein kinase C by teleocidin, and caused half-maximal activation at 25μM (+)-Catechin, which has been reported not to inhibit tumor-promoting activity, did not have any effect on these reactions. The modulation of phorbol ester receptors and inhibition of activation of protein kinase C are considered to be involved in the anti-tumor-pro-moting effect of quercetin in mouse skin. Diet containing 4% or 1% quercetin did not influence the action of teleocidin on mouse skin in a two-stage carcinogenesis experi-ment.

Original languageEnglish
Pages (from-to)526-531
Number of pages6
JournalJapanese Journal of Cancer Research GANN
Volume77
Issue number6
Publication statusPublished - Jan 1 1986
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Horiuchi, T., Fujiki, H., Hakii, H., Suganuma, M., Yamashita, K., & Sugimura, T. (1986). Modulation of phorbol ester receptors in mouse skin by application of quercetin. Japanese Journal of Cancer Research GANN, 77(6), 526-531.