Modulation of sweet responses of taste receptor cells

Ryusuke Yoshida, Mayu Niki, Masafumi Jyotaki, Keisuke Sanematsu, Noriatsu Shigemura, Yuzo Ninomiya

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Taste receptor cells play a major role in detection of chemical compounds in the oral cavity. Information derived from taste receptor cells, such as sweet, bitter, salty, sour and umami is important for evaluating the quality of food components. Among five basic taste qualities, sweet taste is very attractive for animals and influences food intake. Recent studies have demonstrated that sweet taste sensitivity in taste receptor cells would be affected by leptin and endocannabinoids. Leptin is an anorexigenic mediator that reduces food intake by acting on leptin receptor Ob-Rb in the hypothalamus. Endocannabinoids such as anandamide [N-arachidonoylethanolamine (AEA)] and 2-arachidonoyl glycerol (2-AG) are known as orexigenic mediators that act via cannabinoid receptor 1 (CB1) in the hypothalamus and limbic forebrain to induce appetite and stimulate food intake. At the peripheral gustatory organs, leptin selectively suppresses and endocannabinoids selectively enhance sweet taste sensitivity via Ob-Rb and CB1 expressed in sweet sensitive taste cells. Thus leptin and endocannabinoids not only regulate food intake via central nervous systems but also modulate palatability of foods by altering peripheral sweet taste responses. Such reciprocal modulation of leptin and endocannabinoids on peripheral sweet sensitivity may play an important role in regulating energy homeostasis.

Original languageEnglish
Pages (from-to)226-231
Number of pages6
JournalSeminars in Cell and Developmental Biology
Volume24
Issue number3
DOIs
Publication statusPublished - Jan 1 2013

Fingerprint

Endocannabinoids
Leptin
Eating
Cannabinoid Receptors
Hypothalamus
Leptin Receptors
Food Quality
Appetite
Prosencephalon
Mouth
Homeostasis
Central Nervous System
Food

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

Cite this

Modulation of sweet responses of taste receptor cells. / Yoshida, Ryusuke; Niki, Mayu; Jyotaki, Masafumi; Sanematsu, Keisuke; Shigemura, Noriatsu; Ninomiya, Yuzo.

In: Seminars in Cell and Developmental Biology, Vol. 24, No. 3, 01.01.2013, p. 226-231.

Research output: Contribution to journalReview article

Yoshida, Ryusuke ; Niki, Mayu ; Jyotaki, Masafumi ; Sanematsu, Keisuke ; Shigemura, Noriatsu ; Ninomiya, Yuzo. / Modulation of sweet responses of taste receptor cells. In: Seminars in Cell and Developmental Biology. 2013 ; Vol. 24, No. 3. pp. 226-231.
@article{f7cbd94ecad24b7485a95b97c7a37354,
title = "Modulation of sweet responses of taste receptor cells",
abstract = "Taste receptor cells play a major role in detection of chemical compounds in the oral cavity. Information derived from taste receptor cells, such as sweet, bitter, salty, sour and umami is important for evaluating the quality of food components. Among five basic taste qualities, sweet taste is very attractive for animals and influences food intake. Recent studies have demonstrated that sweet taste sensitivity in taste receptor cells would be affected by leptin and endocannabinoids. Leptin is an anorexigenic mediator that reduces food intake by acting on leptin receptor Ob-Rb in the hypothalamus. Endocannabinoids such as anandamide [N-arachidonoylethanolamine (AEA)] and 2-arachidonoyl glycerol (2-AG) are known as orexigenic mediators that act via cannabinoid receptor 1 (CB1) in the hypothalamus and limbic forebrain to induce appetite and stimulate food intake. At the peripheral gustatory organs, leptin selectively suppresses and endocannabinoids selectively enhance sweet taste sensitivity via Ob-Rb and CB1 expressed in sweet sensitive taste cells. Thus leptin and endocannabinoids not only regulate food intake via central nervous systems but also modulate palatability of foods by altering peripheral sweet taste responses. Such reciprocal modulation of leptin and endocannabinoids on peripheral sweet sensitivity may play an important role in regulating energy homeostasis.",
author = "Ryusuke Yoshida and Mayu Niki and Masafumi Jyotaki and Keisuke Sanematsu and Noriatsu Shigemura and Yuzo Ninomiya",
year = "2013",
month = "1",
day = "1",
doi = "10.1016/j.semcdb.2012.08.004",
language = "English",
volume = "24",
pages = "226--231",
journal = "Seminars in Cell and Developmental Biology",
issn = "1084-9521",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Modulation of sweet responses of taste receptor cells

AU - Yoshida, Ryusuke

AU - Niki, Mayu

AU - Jyotaki, Masafumi

AU - Sanematsu, Keisuke

AU - Shigemura, Noriatsu

AU - Ninomiya, Yuzo

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Taste receptor cells play a major role in detection of chemical compounds in the oral cavity. Information derived from taste receptor cells, such as sweet, bitter, salty, sour and umami is important for evaluating the quality of food components. Among five basic taste qualities, sweet taste is very attractive for animals and influences food intake. Recent studies have demonstrated that sweet taste sensitivity in taste receptor cells would be affected by leptin and endocannabinoids. Leptin is an anorexigenic mediator that reduces food intake by acting on leptin receptor Ob-Rb in the hypothalamus. Endocannabinoids such as anandamide [N-arachidonoylethanolamine (AEA)] and 2-arachidonoyl glycerol (2-AG) are known as orexigenic mediators that act via cannabinoid receptor 1 (CB1) in the hypothalamus and limbic forebrain to induce appetite and stimulate food intake. At the peripheral gustatory organs, leptin selectively suppresses and endocannabinoids selectively enhance sweet taste sensitivity via Ob-Rb and CB1 expressed in sweet sensitive taste cells. Thus leptin and endocannabinoids not only regulate food intake via central nervous systems but also modulate palatability of foods by altering peripheral sweet taste responses. Such reciprocal modulation of leptin and endocannabinoids on peripheral sweet sensitivity may play an important role in regulating energy homeostasis.

AB - Taste receptor cells play a major role in detection of chemical compounds in the oral cavity. Information derived from taste receptor cells, such as sweet, bitter, salty, sour and umami is important for evaluating the quality of food components. Among five basic taste qualities, sweet taste is very attractive for animals and influences food intake. Recent studies have demonstrated that sweet taste sensitivity in taste receptor cells would be affected by leptin and endocannabinoids. Leptin is an anorexigenic mediator that reduces food intake by acting on leptin receptor Ob-Rb in the hypothalamus. Endocannabinoids such as anandamide [N-arachidonoylethanolamine (AEA)] and 2-arachidonoyl glycerol (2-AG) are known as orexigenic mediators that act via cannabinoid receptor 1 (CB1) in the hypothalamus and limbic forebrain to induce appetite and stimulate food intake. At the peripheral gustatory organs, leptin selectively suppresses and endocannabinoids selectively enhance sweet taste sensitivity via Ob-Rb and CB1 expressed in sweet sensitive taste cells. Thus leptin and endocannabinoids not only regulate food intake via central nervous systems but also modulate palatability of foods by altering peripheral sweet taste responses. Such reciprocal modulation of leptin and endocannabinoids on peripheral sweet sensitivity may play an important role in regulating energy homeostasis.

UR - http://www.scopus.com/inward/record.url?scp=84875576316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875576316&partnerID=8YFLogxK

U2 - 10.1016/j.semcdb.2012.08.004

DO - 10.1016/j.semcdb.2012.08.004

M3 - Review article

VL - 24

SP - 226

EP - 231

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

IS - 3

ER -