Modulation of taste responsiveness by angiotensin II

Research output: Contribution to journalReview article

Abstract

Angiotensin II and aldosterone are key hormones regulating sodium and water balance. Investigations of the taste system in rat have shown that the amiloride-sensitivity of the taste nerve responses to NaCl is enhanced by aldosterone treatment over a time course of several hours. A recent study further revealed that angiotensin II suppresses the amiloride-sensitivity of the mouse gustatory NaCl responses and enhances sweet taste sensitivity within one hour, without affecting umami, sour and bitter responses. These results suggest the presence of a reciprocal regulatory mechanism of salty taste sensitivity by angiotensin II as an acute suppressor and aldosterone as a slow enhancer in peripheral taste organs, which may play an important role in maintaining sodium homeostasis. Moreover, the possible cross-talk between salty and sweet taste modulation by angiotensin II signaling may optimize sodium and calorie intake.

Original languageEnglish
Pages (from-to)757-764
Number of pages8
JournalFood Science and Technology Research
Volume21
Issue number6
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

angiotensin II
taste sensitivity
Angiotensin II
aldosterone
Aldosterone
Sodium
Modulation
Amiloride
sodium
Hormones
umami
Rats
water balance
homeostasis
energy intake
nerve tissue
hormones
Responsiveness
Water
rats

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering
  • Marketing

Cite this

Modulation of taste responsiveness by angiotensin II. / Shigemura, Noriatsu.

In: Food Science and Technology Research, Vol. 21, No. 6, 01.01.2015, p. 757-764.

Research output: Contribution to journalReview article

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