Modulators of voltage-dependent calcium channels for the treatment of nervous system diseases

Eiki Takahashi, Kimie Niimi

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)

Abstract

Voltage-dependent Ca2+ channels (VDCCs) play important roles in physiological functions and pathological processes of the nervous system. Given that the precise regulation of Ca2+ signaling is important for neuronal processes such as action potential generation, transmitter release, and synaptic plasticity, alterations in Ca2+ current through VDCCs affect the functions of neurons and circuits. Central nervous system (CNS) diseases, including pain, epilepsy, seizure, anxiety, depression, dementia, and stroke, are characterized by an altered balance between excitatory and inhibitory neuronal functions. An efficient way of controlling such diseases is to block or modulate VDCC function. An effective strategy to reduce the likelihood of adverse effects is to develop agents that selectively control the VDCC isoform/subunit involved in the mechanism of the disease in question. This review provides an overview of knowledge on VDCCs, traditional and newly developed therapeutic fields, clinical fields, and the diverse medicinal chemistry of traditional and newly developed VDCC blockers in the CNS based on the scientific and patent literature.

Original languageEnglish
Pages (from-to)96-111
Number of pages16
JournalRecent Patents on CNS Drug Discovery
Volume4
Issue number2
DOIs
Publication statusPublished - 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Drug Discovery
  • Psychiatry and Mental health
  • Pharmacology (medical)

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