Modulatory effect of plasminogen on NMDA-induced increase in intracellular free calcium concentration in rat cultured hippocampal neurons

Kazuhide Inoue, Schuichi Koizumi, Kazuyuki Nakajima, Makoto Hamanoue, Shinichi Kohsaka

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The effect of plasminogen on the intracellular Ca2+ concentration ([Ca]i) was examined in cultured rat hippocampal neurons. Plasminogen (100 nM) did not increase [Ca]i in the presence of tetrodotoxin (TTX, 3 μM) but increased [Ca]i in the absence of TTX. In all the cells which responded to plasminogen (100 nM), NMDA (5 μM) also increased [Ca]i in the presence of TTX. Furthermore, plasminogen (100 nM) enhanced the NMDA-evoked [Ca]i increase, and the potentiation by plasminogen was blocked by an NMDA receptor blocker, 2-amino-phosphonovalerate (APV). These data suggest that plasminogen enhances glutamate-evoked [Ca]i increase through modulation of NMDA receptor in hippocampal neurons.

Original languageEnglish
Pages (from-to)87-90
Number of pages4
JournalNeuroscience Letters
Volume179
Issue number1-2
DOIs
Publication statusPublished - Sep 26 1994
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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