MOG antibody disease manifesting as progressive cognitive deterioration and behavioral changes with primary central nervous system vasculitis

Toshikazu Baba, Koji Shinoda, Mitsuru Watanabe, Shoko Sadashima, Dai Matsuse, Noriko Isobe, Ryo Yamasaki, Kimihiko Kaneko, Toshiyuki Takahashi, Toru Iwaki, Jun ichi Kira

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We report a 60-year-old male with anti-myelin oligodendrocyte glycoprotein (MOG) antibody who developed progressive cognitive deterioration and behavioral changes, with no other focal signs, over 9 months. MRI showed numerous T2-hyperintense lesions with partial contrast enhancement in white and grey matter of cerebrum, cerebellum and spinal cord. A brain biopsy revealed perivascular inflammatory cell infiltration, disturbed vascular continuity and no demyelination, indicative of a lymphocytic pattern of primary CNS vasculitis (PCNSV). Contrast enhancement disappeared after immunotherapy; however, cognitive impairment was not improved. Neurologists should note that MOG antibody disease can present as immunotherapy-resistant progressive cognitive impairment with PCNSV-like histopathology.

Original languageEnglish
Pages (from-to)48-50
Number of pages3
JournalMultiple Sclerosis and Related Disorders
Volume30
DOIs
Publication statusPublished - May 2019

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

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