Molecular and functional properties of metabotropic glutamate receptors in the brain

H. Sugiyama, K. Nakamura, F. Katsuki, R. Minakami

Research output: Contribution to journalArticle

Abstract

We examined the molecular structural and functional properties of metabotropic glutamate receptors (mGluRs) in rat brains, especially the subtypes 1 and 5 which are known to stimulate phosphoinositide (PI) metabolism. We found that mGluR5 as well as mGluR1 has structural variants, most likely derived by the alternative splicing of the gene. We also found that, under certain circumstances, mGluR1 could inhibit, instead of stimulate, PI turnover in a G protein-dependent manner. This finding may give a possible explanation for the discrepancy we observed between the postnatal development of glutamate-stimulated PI turnover and the postnatal ontogenesis of mGluRs.

Original languageEnglish
Pages (from-to)29-31
Number of pages3
JournalBiomedical Research
Volume15
Issue numberSUPPL. 1
Publication statusPublished - Jan 1 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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    Sugiyama, H., Nakamura, K., Katsuki, F., & Minakami, R. (1994). Molecular and functional properties of metabotropic glutamate receptors in the brain. Biomedical Research, 15(SUPPL. 1), 29-31.