Molecular basis for pre-TCR-mediated autonomous signaling

Shou Yamasaki, Takashi Saito

    Research output: Contribution to journalReview articlepeer-review

    49 Citations (Scopus)

    Abstract

    The pre-T-cell receptor (pre-TCR) is a multimeric complex composed of a nascent TCRβ chain, an invariant pre-TCRα (pTα) chain and CD3 molecules, and is crucial for early T-cell development. Despite its structural similarity to the mature αβTCR, which requires MHC-antigen for receptor triggering, the pre-TCR is proposed to initiate signals in a ligand-independent manner. However, the molecular mechanism underlying the autonomous signaling is still unclear. Recent studies have revealed that pTα possesses unique characteristics that promote autonomous signaling. In this review, we summarize current data relating to the molecular mechanism underlying the initiation of pre-TCR-mediated autonomous signaling.

    Original languageEnglish
    Pages (from-to)39-43
    Number of pages5
    JournalTrends in Immunology
    Volume28
    Issue number1
    DOIs
    Publication statusPublished - Jan 1 2007

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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