Molecular biology of human angiotensin II receptor

K. Ohnaka, R. Takayanagi, H. Nawata

Research output: Contribution to journalReview article

Abstract

Pharmacological studies have revealed the presence of two different subtypes (AT1 and AT2) for angiotensin II (Ang II) receptor. Recently, bovine and rat cDNAs of AT1 receptor were cloned by expression cloning. We have isolated a cDNA encoding human AT1 receptor from a human liver cDNA library, using rat AT1 receptor cDNA as a probe. Human AT1 receptor consists of 359 amino acid residues with a relative Mr of 41,060 and seven transmembrane segments, and was highly homologous to those of bovine, rat and mouse AT1 receptors. Southern blot analysis suggested that human AT1 receptor is a single copy gene.

Original languageEnglish
Pages (from-to)1568-1574
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Volume51
Issue number6
Publication statusPublished - Jun 1993

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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