Molecular design of hard-soft ditopic metal-binding sites on a calix[4]arene platform

Kwang Nak Koh, Tomoyuki Imada, Takeshi Nagasaki, Seiji Shinkai

Research output: Contribution to journalArticle

25 Citations (Scopus)


Ditopic "hard"-"soft" metal binding-sites composed of four EtS(CH2)nNHCOCH2O-groups were designed for the first time on a calix[4]arene platform. N = 2 is too short to form a bimetallic complex whereas n = 6 is long enough to accept two metal ions. 1H NMR spectral studies established that although Cd2+ bound to the "soft" binding-site excludes Na+ out of the "hard" binding-site, Ag+ can be co-existent with Na+ in the ionophoric cavity.

Original languageEnglish
Pages (from-to)4157-4160
Number of pages4
JournalTetrahedron Letters
Issue number24
Publication statusPublished - Jun 13 1994


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this