Molecular design of hard-soft ditopic metal-binding sites on a calix[4]arene platform

Kwang Nak Koh, Tomoyuki Imada, Takeshi Nagasaki, Seiji Shinkai

Research output: Contribution to journal › Article

25 Citations (Scopus)

Abstract

Ditopic "hard"-"soft" metal binding-sites composed of four EtS(CH2)nNHCOCH2O-groups were designed for the first time on a calix[4]arene platform. N = 2 is too short to form a bimetallic complex whereas n = 6 is long enough to accept two metal ions. 1H NMR spectral studies established that although Cd2+ bound to the "soft" binding-site excludes Na+ out of the "hard" binding-site, Ag+ can be co-existent with Na+ in the ionophoric cavity.

Original languageEnglish
Pages (from-to)4157-4160
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number24
DOIs
Publication statusPublished - Jun 13 1994

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Metals
Binding Sites
Metal ions
Nuclear magnetic resonance
Ions
calix(4)arene
hard metal
Proton Magnetic Resonance Spectroscopy

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Molecular design of hard-soft ditopic metal-binding sites on a calix[4]arene platform. / Koh, Kwang Nak; Imada, Tomoyuki; Nagasaki, Takeshi; Shinkai, Seiji.

In: Tetrahedron Letters, Vol. 35, No. 24, 13.06.1994, p. 4157-4160.

Research output: Contribution to journal › Article

Koh, KN, Imada, T, Nagasaki, T & Shinkai, S 1994, 'Molecular design of hard-soft ditopic metal-binding sites on a calix[4]arene platform', Tetrahedron Letters, vol. 35, no. 24, pp. 4157-4160. https://doi.org/10.1016/S0040-4039(00)73138-8
Koh KN, Imada T, Nagasaki T, Shinkai S. Molecular design of hard-soft ditopic metal-binding sites on a calix[4]arene platform. Tetrahedron Letters. 1994 Jun 13;35(24):4157-4160. https://doi.org/10.1016/S0040-4039(00)73138-8
Koh, Kwang Nak ; Imada, Tomoyuki ; Nagasaki, Takeshi ; Shinkai, Seiji. / Molecular design of hard-soft ditopic metal-binding sites on a calix[4]arene platform. In: Tetrahedron Letters. 1994 ; Vol. 35, No. 24. pp. 4157-4160.
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