Ditopic "hard"-"soft" metal binding-sites composed of four EtS(CH2)nNHCOCH2O-groups were designed for the first time on a calixarene platform. N = 2 is too short to form a bimetallic complex whereas n = 6 is long enough to accept two metal ions. 1H NMR spectral studies established that although Cd2+ bound to the "soft" binding-site excludes Na+ out of the "hard" binding-site, Ag+ can be co-existent with Na+ in the ionophoric cavity.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry