Molecular design of synthetic receptors with dynamic, imprinting, and allosteric functions

Seiji Shinkai, Masayuki Takeuchi

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Sugar recognition in an aqueous system has been achieved using a boronic acid-diol interaction. Combination with an intramolecular amino group has enabled us to read out the binding process as a change in the fluorescence intensity. This novel sugar-sensing method has been combined with a concept of "molecular machinery", providing a new guest-binding mode with allosteric functions. When this method is combined with a concept of "molecular imprinting", it becomes possible to design sugar-selective receptors created by a combinatorial method. The sugar recognition event is useful as a trigger to control molecular assemblies such as micelles, membranes, vesicles, and gels.

Original languageEnglish
Pages (from-to)40-51
Number of pages12
JournalBulletin of the Chemical Society of Japan
Volume78
Issue number1
DOIs
Publication statusPublished - Jan 1 2005

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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