Molecular epidemiology of major depressive disorder

Chikako Kiyohara, Kouichi Yoshimasu

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Major depressive disorder causes significant morbidity, affecting peoples ability to work, function in relationships, and engage in social activities. Moreover, major depressive disorder increases the risk of suicidal ideation, attempted suicide and death by completed suicide. There is evidence that chronic stress can cause major depressive disorder. As for genetic factors, only minor susceptibility genes have been reliably identified. The serotonin system provides a logical source of susceptibility genes for depression, because this system is the target of selective serotonin reuptake-inhibitor drugs that are effective in treating depression. The 5-hydroxytryptamine (serotonin) transporter (5-HTT) has received particular attention because it is involved in the reuptake of serotonin at brain synapses. One common polymorphic variant of the 5-HTT-linked polymorphic region (5-HTTLPR), which affects the promoter of the 5-HTT gene, causes reduced uptake of the neurotransmitter serotonin into the presynaptic cells in the brain. The authors discussed the relationship between genetic polymorphisms and major depressive disorder, with special emphasis on the 5-HTTTLPR polymorphism. As the 5-HTTLPR polymorphism was significantly associated with an increased risk of major depressive disorder, the 5-HTT gene may be a candidate for a major depressive disorder susceptibility gene. As major depressive disorder is a multifactorial disease, an improved understanding of the interplay of environmental and genetic polymorphisms at multiple loci may help identify individuals who are at increased risk for major depressive disorder. Hopefully, in the future we will be able to screen for major depressive disorder susceptibility by using specific biomarkers.

Original languageEnglish
Pages (from-to)71-87
Number of pages17
JournalEnvironmental health and preventive medicine
Volume14
Issue number2
DOIs
Publication statusPublished - Mar 1 2009

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Molecular Epidemiology
Major Depressive Disorder
Serotonin
Serotonin Plasma Membrane Transport Proteins
Genes
Genetic Polymorphisms
Depression
Attempted Suicide
Suicidal Ideation
Aptitude
Serotonin Uptake Inhibitors
Brain
Synapses
Suicide
Neurotransmitter Agents
Biomarkers
Morbidity

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Molecular epidemiology of major depressive disorder. / Kiyohara, Chikako; Yoshimasu, Kouichi.

In: Environmental health and preventive medicine, Vol. 14, No. 2, 01.03.2009, p. 71-87.

Research output: Contribution to journalReview article

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