Molecular identification of a taste receptor gene for trehalose in drosophila

Hiroshi Ishimoto, Akira Matsumoto, Teiichi Tanimura

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The molecular nature of sweet taste receptors has not been fully explored. Employing a differential screening strategy, we identified a taste receptor gene, Tre1, that controls the taste sensitivity to trehalose in Drosophila melanogaster. The Tre1 gene encodes a novel protein with similarity to G protein-coupled seven-transmembrane receptors. Disruption of the Tre1 gene lowered the taste sensitivity to trehalose, whereas sensitivities to other sugars were unaltered. Overexpression of the Tre1 gene restored the taste sensitivity to trehalose in the Tre1 deletion mutant. The Tre 1 gene is expressed in taste sensory cells. These results provide direct evidence that Tre1 encodes a putative taste receptor for trehalose in Drosophila.

Original languageEnglish
Pages (from-to)116-119
Number of pages4
JournalScience
Volume289
Issue number5476
DOIs
Publication statusPublished - Jul 7 2000

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Trehalose
Drosophila
Genes
Drosophila melanogaster

All Science Journal Classification (ASJC) codes

  • General

Cite this

Molecular identification of a taste receptor gene for trehalose in drosophila. / Ishimoto, Hiroshi; Matsumoto, Akira; Tanimura, Teiichi.

In: Science, Vol. 289, No. 5476, 07.07.2000, p. 116-119.

Research output: Contribution to journalArticle

Ishimoto, Hiroshi ; Matsumoto, Akira ; Tanimura, Teiichi. / Molecular identification of a taste receptor gene for trehalose in drosophila. In: Science. 2000 ; Vol. 289, No. 5476. pp. 116-119.
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