Molecular imprinted polyacrylic acids based QCM sensor array for recognition of organic acids in body odor

Sunil K. Jha, Chuanjun Liu, Kenshi Hayashi

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

In present research, a novel volatile acids imprinted 3-element quartz crystal microbalance (QCM) sensor array has been designed for the selective recognition of organic acids odor. The target organic acids have been previously assigned as significant biomarker in human body odor and human waste odor. This is also confirmed with solid phase micro-extraction gas chromatography-mass spectrometer (SPME-GC-MS) characterization of body odor samples in present study. Polyacrylic acid (PAA) polymer has been used to prepare three selective molecular imprinted polymers (MIPs). MIP films were coated on the surface of QCM electrodes. Performance of MIP based QCM sensor array has been studied by exposing different concentrations of propenoic acid, hexanoic acid, and octanoic acid in singly and their binary mixtures. The response time and recovery time were 5 s and 14 s, respectively for one of the MIP coated QCM sensor to a typical binary mixture of acids odor. Frequency shift of QCM due to odor molecules adsorption in thin layer of MIP was measured as sensor signal. Sensor signal response matrix has been analyzed with principal component analysis (PCA) and support vector machine (SVM) methods for the odor recognition. The acid odors were identified effectively in principal component (PC) space. SVM classifier results 70-76% recognition rate for three classes of binary odor. While excluding the binary mixture of propenoic acid and octanoic acid the average recognition rate approaches to 95% in 3-fold cross validation of SVM classifier.

Original languageEnglish
Pages (from-to)74-87
Number of pages14
JournalSensors and Actuators, B: Chemical
Volume204
DOIs
Publication statusPublished - Dec 1 2014

Fingerprint

carbopol 940
odors
Quartz crystal microbalances
Organic acids
Sensor arrays
Odors
quartz crystals
microbalances
acids
Acids
sensors
Polymers
Binary mixtures
polymers
Support vector machines
binary mixtures
classifiers
Sensors
Classifiers
human wastes

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

Molecular imprinted polyacrylic acids based QCM sensor array for recognition of organic acids in body odor. / Jha, Sunil K.; Liu, Chuanjun; Hayashi, Kenshi.

In: Sensors and Actuators, B: Chemical, Vol. 204, 01.12.2014, p. 74-87.

Research output: Contribution to journalArticle

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