'Molecular-imprinting' in polyion complexes which creates the 'memory' for the AMP template

Yasumasa Kanekiyo, Yoshiyuki Ono, Kazuhiko Inoue, Masahito Sano, Seiji Shinkai

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The formation of a polyion complex precipitate was applied to molecular imprinting for the first time. Polyanion containing boronic acid units can sustain AMP by a boronate-cis-diol interaction. When this polyanion forms a polyion complex with polycation according to 1 : 1 cation-anion stoichiometry, the phosphate anionic charges introduced into the polyanion by the AMP complexation are also counted. Thus, after removal of AMP from the polyion complex a 'cleft' which has the memory for the AMP template is created. It was proved that this cleft shows high affinity with AMP. We also noticed that the removal and re-binding processes for AMP coincide with the swelling and deswelling phenomena of this polyion complex.

Original languageEnglish
Pages (from-to)557-561
Number of pages5
JournalJournal of the Chemical Society. Perkin Transactions 2
Issue number3
Publication statusPublished - Mar 1 1999
Externally publishedYes

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Adenosine Monophosphate
Data storage equipment
Boronic Acids
Complexation
Stoichiometry
Anions
Swelling
Cations
Precipitates
Phosphates
polyanions

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

'Molecular-imprinting' in polyion complexes which creates the 'memory' for the AMP template. / Kanekiyo, Yasumasa; Ono, Yoshiyuki; Inoue, Kazuhiko; Sano, Masahito; Shinkai, Seiji.

In: Journal of the Chemical Society. Perkin Transactions 2, No. 3, 01.03.1999, p. 557-561.

Research output: Contribution to journalArticle

Kanekiyo, Yasumasa ; Ono, Yoshiyuki ; Inoue, Kazuhiko ; Sano, Masahito ; Shinkai, Seiji. / 'Molecular-imprinting' in polyion complexes which creates the 'memory' for the AMP template. In: Journal of the Chemical Society. Perkin Transactions 2. 1999 ; No. 3. pp. 557-561.
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